ArticleThe Journal of physiology1998
Laminar difference in GABA uptake and GAT-1 expression in rat CA1.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Dynamic and Homeostatic Neuron-Astrocyte Interactions at GABAergic Synapses.Neurochemical research · 2025Review
- Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.International journal of molecular sciences · 2017Review
- Epileptiform activity and spreading depolarization in the blood-brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition and synaptic plasticity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Structure, function, and plasticity of GABA transporters.Frontiers in cellular neuroscience · 2014Review
- Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Review
- Tonic GABAA conductance decreases membrane time constant and increases EPSP-spike precision in hippocampal pyramidal neurons.Frontiers in neural circuits · 2013Article
- A TRP among the astrocytes.The Journal of physiology · 2013Review
- GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidus.The European journal of neuroscience · 2012Article
- Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus.The European journal of neuroscience · 2011Article
- Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia.Frontiers in systems neuroscience · 2011Article
- Modulation and function of the autaptic connections of layer V fast spiking interneurons in the rat neocortex.The Journal of physiology · 2010Article
- Modulation of spontaneous and GABA-evoked tonic alpha4beta3delta and alpha4beta3gamma2L GABAA receptor currents by protein kinase A.Journal of neurophysiology · 2010Article
- Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters.The Journal of physiology · 2009Article
- Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor.Neuron · 2009Article
- Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior.Molecular psychiatry · 2009Article
- Substrate-mediated regulation of gamma-aminobutyric acid transporter 1 in rat brain.Neuropharmacology · 2008Article
- Turnover rate of the gamma-aminobutyric acid transporter GAT1.The Journal of membrane biology · 2007Article
- The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus.The Journal of physiology · 2007Article
- Expression of the gamma-aminobutyric acid (GABA) plasma membrane transporter-1 in monkey and human retina.Investigative ophthalmology & visual science · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The axonal plexus of most hippocampal interneurons is restricted to certain strata within the target region. This lamination suggests a possible functional heterogeneity of inhibitory synapses between different interneurons and CA1 pyramidal cells. 2. We therefore compared inhibitory postsynaptic potentials (IPSPs) and currents (IPSCs) in CA1 pyramidal cells, which were evoked from two stimulation sites (stratum oriens and stratum radiatum). Stimulation in stratum oriens yielded faster decaying IPSPs and IPSCs than stimulation in stratum radiatum. 3. IPSP and IPSC kinetics were regulated by GABA uptake in both layers as indicated by the prolongation of the signals under tiagabine, a GAT-1 (neuronal GABA plasma membrane transporter)-specific GABA-uptake blocker. However, the effect of tiagabine was significantly more pronounced following stimulation in stratum radiatum than in stratum oriens (prolongation of IPSC half-decay time by 167 vs. 115 %, respectively). 4. In situ hybridization with antisense mRNA for the GABA-synthesizing enzyme glutamate decarboxylase (GAD65/67) and the GABA transporter GAT-1 showed that the proportion of interneurons expressing GAT-1 was lower in stratum oriens than in stratum radiatum/lacunosum-moleculare. 5. From these functional and molecular data we conclude that the regulation of IPSP and IPSC kinetics in CA1 pyramidal cells by neuronal GABA uptake differs between layers. Our findings suggest that this laminar difference is caused by a lower expression of GAT-1 in interneurons in stratum oriens than in stratum radiatum/lacunosum-moleculare.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.