ArticleRNA (New York, N.Y.)1998
Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control.
Article in RNA (New York, N.Y.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- Evaluation of novel computational methods to identify RNA-binding protein footprints from structural data.RNA (New York, N.Y.) · 2025Article
- CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells.Scientific reports · 2025Article
- Molecular basis for the activation of human spliceosome.Nature communications · 2024Article
- RNAseq analysis of oocyte maturation from the germinal vesicle stage to metaphase II in pig and human.PloS one · 2024Article
- Arabidopsis AtPRP17 functions in embryo development by regulating embryonic patterning.Planta · 2021Article
- The functional study of human proteins using humanized yeast.Journal of microbiology (Seoul, Korea) · 2020Review
- Article
- Evaluation of artificial selection in Standard Poodles using whole-genome sequencing.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- HBx-induced MiR-1269b in NF-κB dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells.Journal of translational medicine · 2016Article
- The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability.DNA repair · 2014Review
- Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.PloS one · 2011Article
- A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.Molecular cell · 2009Article
- Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.Molecular and cellular biology · 2006Article
- Specific role of the SR protein splicing factor B52 in cell cycle control in Drosophila.Molecular and cellular biology · 2006Article
- A novel SR-related protein is required for the second step of Pre-mRNA splicing.Molecular and cellular biology · 2005Article
- Origins of recently gained introns in Caenorhabditis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The Saccharomyces cerevisiae gene CDC40/PRP17 controls cell cycle progression through splicing of the ANC1 gene.Nucleic acids research · 2004Article
- Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint.Nucleic acids research · 2002Article
- Reversible inhibition of the second step of splicing suggests a possible role of zinc in the second step of splicing.Nucleic acids research · 2002Article
- Characterization of interactions among the Cef1p-Prp19p-associated splicing complex.RNA (New York, N.Y.) · 2002Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The PRP17 gene of the yeast Saccharomyces cerevisiae encodes a protein that participates in the second step of the splicing reaction. It was found recently that the yeast PRP17 gene is identical to the cell division cycle CDC40 gene. The PRP17/CDC40 gene codes for a protein with several copies of the WD repeat, a motif found in a large family of proteins that play important roles in signal transduction, cell cycle progression, splicing, transcription, and development. In this report, we describe the identification of human, nematode, and fission yeast homologues of the PRP17/CDC40 gene of S. cerevisiae. The newly identified proteins share homology with the budding yeast protein throughout their entire sequence, with the similarity being greatest in the C-terminal two thirds that includes the conserved WD repeats. We show that a yeast-human chimera, carrying the C-terminal two thirds of the hPRP17 protein, is able to complement the cell cycle and splicing defects of a yeast prp17 mutant. Moreover, the yeast and yeast-human chimeric proteins co-precipitate the intron-exon 2 lariat intermediate and the intron lariat product, providing evidence that these proteins are spliceosome-associated. These results show the functional conservation of the Prp17 proteins in evolution and suggest that the second step of splicing takes place by a similar mechanism throughout eukaryotes.
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