ArticleJapanese journal of cancer research : Gann1998
Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer.
Article in Japanese journal of cancer research : Gann, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Human 8-oxoguanine DNA glycosylase gene polymorphism (Ser326Cys) and cancer risk: updated meta-analysis.Oncotarget · 2017Pooled it
- Association between hOGG1 polymorphism rs1052133 and gastric cancer.Oncotarget · 2017Pooled it
- The hOGG1 Ser326Cys polymorphism contributes to digestive system cancer susceptibility: evidence from 48 case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- A systematic review and meta-analysis of the association between OGG1 Ser326Cys polymorphism and cancers.Medical oncology (Northwood, London, England) · 2015Pooled it
- Association of hOGG1 Ser326Cys polymorphism with gastric cancer risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- Thermostability and excision activity of polymorphic forms of hOGG1.BMC research notes · 2019Article
- Reduction-oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Review
- Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan.World journal of gastroenterology · 2016Article
- Effect of 8-oxoguanine glycosylase deficiency on aflatoxin B1 tumourigenicity in mice.Mutagenesis · 2015Article
- Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes.Oncotarget · 2014Article
- DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma.Molecular biology reports · 2011Article
- OGG1 Ser326Cys polymorphism and susceptibility to esophageal cancer in low and high at-risk populations of northern India.Journal of gastrointestinal cancer · 2010Article
- Single nucleotide polymorphisms in DNA repair genes and prostate cancer risk.Methods in molecular biology (Clifton, N.J.) · 2009Review
- DNA repair dysfunction in gastrointestinal tract cancers.Cancer science · 2008Review
- Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors.Molecular cancer · 2008Article
- Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice.Oncogene · 2006Article
- Phosphorylation of human oxoguanine DNA glycosylase (alpha-OGG1) modulates its function.Nucleic acids research · 2005Article
- Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant.Nucleic acids research · 2005Article
- hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations.Cancer science · 2004Article
- Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients.Human genetics · 2004Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA glycosylase, encoded by the hOGG1 gene, repairs 8-hydroxyguanine (oh8Gua), which is an oxidatively damaged mutagenic base. To clarify whether the DNA repair activity of hOGG1 protein is involved in gastric carcinogenesis, we examined 9 gastric cancer cell lines and 35 primary gastric cancers for mutations and genetic polymorphisms of the hOGG1 gene by polymerase chain reaction-single strand conformation polymorphism analysis. A G-to-A transition was detected in a gastric cancer cell line, MKN1. This nucleotide change caused the conversion of the amino acid from Arg to His at codon 154, which is located in a domain highly conserved among human, mouse, and yeast OGG1 proteins. No mutation was detected in primary gastric cancers. We compared the distribution of the polymorphic alleles associated with enzymatic activity (hOGG1-Ser326 vs. hOGG1-Cys326) between 35 gastric cancer patients and 42 healthy individuals. Although the frequency of the Cys326 allele, associated with low enzymatic activity, in gastric cancer patients was a little higher than that in healthy individuals, the difference did not reach statistical significance. These results suggest that low hOGG1 activity due to mutations and genetic polymorphisms is involved in the development of only a small subset of gastric cancers.
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