ArticleJournal of bacteriology1998
Legionella pneumophila catalase-peroxidases: cloning of the katB gene and studies of KatB function.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
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- Persistence of the bacterial pathogen Granulibacter bethesdensis in chronic granulomatous disease monocytes and macrophages lacking a functional NADPH oxidase.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Molecular diversity and high virulence of Legionella pneumophila strains isolated from biofilms developed within a warm spring of a thermal spa.BMC microbiology · 2013Article
- Rhodococcus equi's extreme resistance to hydrogen peroxide is mainly conferred by one of its four catalase genes.PloS one · 2012Article
- An ortholog of OxyR in Legionella pneumophila is expressed postexponentially and negatively regulates the alkyl hydroperoxide reductase (ahpC2D) operon.Journal of bacteriology · 2008Article
- Transcriptional profiling of Bacillus anthracis during infection of host macrophages.Infection and immunity · 2007Article
- Environmental mimics and the Lvh type IVA secretion system contribute to virulence-related phenotypes of Legionella pneumophila.Infection and immunity · 2007Article
- Compensatory functions of two alkyl hydroperoxide reductases in the oxidative defense system of Legionella pneumophila.Journal of bacteriology · 2006Article
- Icm/dot-independent entry of Legionella pneumophila into amoeba and macrophage hosts.Infection and immunity · 2004Article
- Genetic evidence that Legionella pneumophila RpoS modulates expression of the transmission phenotype in both the exponential phase and the stationary phase.Infection and immunity · 2004Article
- Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication.Molecular microbiology · 2003Article
- Legionella pneumophila catalase-peroxidases are required for proper trafficking and growth in primary macrophages.Infection and immunity · 2003Article
- Lateral gene transfer (LGT) between Archaea and Escherichia coli is a contributor to the emergence of novel infectious disease.BMC infectious diseases · 2003Article
- Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infection.Infection and immunity · 2001Article
- Type II protein secretion is a subset of the PilD-dependent processes that facilitate intracellular infection by Legionella pneumophila.Infection and immunity · 2001Article
- Catalase-peroxidases of Legionella pneumophila: cloning of the katA gene and studies of KatA function.Journal of bacteriology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legionella pneumophila, the causative organism of Legionnaires' pneumonia, is spread by aerosolization from man-made reservoirs, e.g. , water cooling towers and air conditioning ducts, whose nutrient-poor conditions are conducive to entrance into stationary phase. Exposure to starvation conditions is known to induce several virulence traits in L. pneumophila. Since catalase-peroxidases have been extremely useful markers of the stationary-phase response in many bacterial species and may be an avenue for identifying virulence genes in L. pneumophila, an investigation of these enzymes was initiated. L. pneumophila was shown to contain two bifunctional catalase-peroxidases and to lack monofunctional catalase and peroxidase. The gene encoding the KatB catalase-peroxidase was cloned and sequenced, and lacZ fusion and null mutant strains were constructed. Null mutants in katB are delayed in the infection and lysis of cultured macrophage-like cell lines. KatB is similar to the KatG catalase-peroxidase of Escherichia coli in its 20-fold induction during exponential growth and in playing a role in resistance to hydrogen peroxide. Analysis of the changes in katB expression and in the total catalase and peroxidase activity during growth indicates that the 8- to 10-fold induction of peroxidase activity that occurs in stationary phase is attributable to KatA, the second L. pneumophila catalase-peroxidase.
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