ArticleJournal of bacteriology1998
A chaperone in the HSP70 family controls production of extracellular fibrils in Myxococcus xanthus.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 71 citations in OpenAlex.
- DnaK duplication and specialization in bacteria correlates with increased proteome complexity.mSystems · 2024Article
- During heat stress in Myxococcus xanthus, the CdbS PilZ domain protein, in concert with two PilZ-DnaK chaperones, perturbs chromosome organization and accelerates cell death.PLoS genetics · 2023Article
- Article
- The type IV pilus assembly ATPase PilB functions as a signaling protein to regulate exopolysaccharide production in Myxococcus xanthus.Scientific reports · 2017Article
- Exposure of Bacterial Biofilms to Electrical Current Leads to Cell Death Mediated in Part by Reactive Oxygen Species.PloS one · 2016Article
- Cyclic Di-GMP Regulates Type IV Pilus-Dependent Motility in Myxococcus xanthus.Journal of bacteriology · 2016Article
- Multiple chaperonins in bacteria--novel functions and non-canonical behaviors.Cell stress & chaperones · 2015Review
- Article
- Phenotypic profiling of ABC transporter coding genes in Myxococcus xanthus.Frontiers in microbiology · 2014Article
- Type IV pilus proteins form an integrated structure extending from the cytoplasm to the outer membrane.PloS one · 2013Article
- MasABK proteins interact with proteins of the type IV pilin system to affect social motility of Myxococcus xanthus.PloS one · 2013Article
- The clpB gene is involved in the stress response of Myxococcus xanthus during vegetative growth and development.Microbiology (Reading, England) · 2012Article
- A Clp/Hsp100 chaperone functions in Myxococcus xanthus sporulation and self-organization.Journal of bacteriology · 2012Article
- Gliding motility revisited: how do the myxobacteria move without flagella?Microbiology and molecular biology reviews : MMBR · 2010Review
- PilA localization affects extracellular polysaccharide production and fruiting body formation in Myxococcus xanthus.Molecular microbiology · 2010Article
- Myxococcus xanthus viability depends on groEL supplied by either of two genes, but the paralogs have different functions during heat shock, predation, and development.Journal of bacteriology · 2010Article
- Independence and interdependence of Dif and Frz chemosensory pathways in Myxococcus xanthus chemotaxis.Molecular microbiology · 2008Article
- Triple mutants uncover three new genes required for social motility in Myxococcus xanthus.Genetics · 2007Article
- The orphan response regulator DigR is required for synthesis of extracellular matrix fibrils in Myxococcus xanthus.Journal of bacteriology · 2006Article
- Transposon insertions of magellan-4 that impair social gliding motility in Myxococcus xanthus.Genetics · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Three independent Tn5-lac insertions in the S1 locus of Myxococcus xanthus inactivate the sglK gene, which is nonessential for growth but required for social motility and multicellular development. The sequence of sglK reveals that it encodes a homologue of the chaperone HSP70 (DnaK). The sglK gene is cotranscribed with the upstream grpS gene, which encodes a GrpE homologue. Unlike sglK, grpS is not required for social motility or development. Wild-type M. xanthus is encased in extracellular polysaccharide filaments associated with the multimeric fibrillin protein. Mutations in sglK inhibit cell cohesion, the binding of Congo red, and the synthesis or secretion of fibrillin, indicating that sglK mutants do not make fibrils. The fibR gene, located immediately upstream of the grpS-sglK operon, encodes a product which is predicted to have a sequence similar to those of the repressors of alginate biosynthesis in Pseudomonas aeruginosa and Pseudomonas putida. Inactivation of fibR leads to the overproduction of fibrillin, suggesting that M. xanthus fibril production and Pseudomonas alginate production are regulated in analogous ways. M. xanthus and Pseudomonas exopolysaccharides may play similar roles in a mechanism of social motility conserved in these gram-negative bacteria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.