ArticleJournal of virology1998
A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
- Review
- Review
- Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination.Brain pathology (Zurich, Switzerland) · 2021Article
- Genotypic Regulation of Type I Interferon Induction Pathways by Frameshift (F) Proteins of Hepatitis C Virus.Journal of virology · 2020Article
- Characterization of Plaque-Sized Variants of Daniel's (DA) Strain in Theiler's Virus-Induced Epilepsy.Scientific reports · 2019Article
- A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.PLoS pathogens · 2018Article
- AMP-activated protein kinase phosphorylates EMCV, TMEV and SafV leader proteins at different sites.Virology · 2014Article
- Mutation of the Theiler's virus leader protein zinc-finger domain impairs apoptotic activity in murine macrophages.Virus research · 2013Article
- Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L.PLoS pathogens · 2013Article
- Evolution of viral proteins originated de novo by overprinting.Molecular biology and evolution · 2012Article
- Theiler's virus L* protein is targeted to the mitochondrial outer membrane.Journal of virology · 2011Article
- Viral security proteins: counteracting host defences.Nature reviews. Microbiology · 2010Review
- Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis.The American journal of pathology · 2010Article
- Theiler's murine encephalomyelitis virus L* amino acid position 93 is important for virus persistence and virus-induced demyelination.Journal of virology · 2010Article
- Theiler's murine encephalomyelitis virus leader protein is the only nonstructural protein tested that induces apoptosis when transfected into mammalian cells.Journal of virology · 2009Article
- Different subcellular localization of Theiler's murine encephalomyelitis virus leader proteins of GDVII and DA strains in BHK-21 cells.Journal of virology · 2009Article
- Antiapoptotic activity of the cardiovirus leader protein, a viral "security" protein.Journal of virology · 2009Article
- Cardioviruses are genetically diverse and cause common enteric infections in South Asian children.Journal of virology · 2009Article
- Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein.The Journal of general virology · 2009Article
- A translatable molecular approach to determining CD8 T-cell epitopes in TMEV infection.Human immunology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TO subgroup strains of Theiler's murine encephalomyelitis virus (TMEV) induce a persistent central nervous system infection and demyelinating disease in mice. This disease serves as an experimental model of multiple sclerosis (MS) because the two diseases have similar inflammatory white matter pathologies and because the immune system appears to mediate demyelination in both processes. We previously reported (H. H. Chen, W. P. Wong, L. Zhang, P. L. Ward, and R. P. Roos, Nat. Med. 1:927-931, 1995) that TO subgroup strains use an alternative initiation codon (in addition to the AUG used to synthesize the picornavirus polyprotein from one long open reading frame) to translate L*, a novel protein that is out of frame with the polyprotein and which plays a key role in the demyelinating disease. We now demonstrate that L* has antiapoptotic activity in macrophage cells and is critical for virus persistence. The antiapoptotic action of L* as well as the differential translation of L* and virion capsid proteins may foster virus persistence in macrophages and interfere with virus clearance. The regulation of apoptotic activity in inflammatory cells may be important in the pathogenesis of TMEV-induced demyelinating disease as well as MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.