ArticleGenes & development1998
Yeast telomeres exert a position effect on recombination between internal tracts of yeast telomeric DNA.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance.bioRxiv : the preprint server for biology · 2025Article
- Imaging assay to probe the role of telomere length shortening on telomere-gene interactions in single cells.Chromosoma · 2021Article
- Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends.PLoS genetics · 2016Article
- Genomic integrity and the ageing brain.Nature reviews. Neuroscience · 2015Review
- Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.Genes & development · 2014Article
- The enigmatic conservation of a Rap1 binding site in the Saccharomyces cerevisiae HMR-E silencer.G3 (Bethesda, Md.) · 2012Article
- Principles of chromosomal organization: lessons from yeast.The Journal of cell biology · 2011Review
- Article
- The transcriptional repressor activator protein Rap1p is a direct regulator of TATA-binding protein.The Journal of biological chemistry · 2008Article
- Human Rad51 protein displays enhanced homologous pairing of DNA sequences resembling those at genetically unstable loci.Nucleic acids research · 2006Article
- Meiotic instability of chicken ultra-long telomeres and mapping of a 2.8 megabase array to the W-sex chromosome.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Article
- A function for subtelomeric DNA in Saccharomyces cerevisiae.Genetics · 2003Article
- Article
- High frequency mitotic gene conversion in genetic hybrids of the oomycete Phytophthora sojae.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.The EMBO journal · 2001Article
- Insertion of a telomere repeat sequence into a mammalian gene causes chromosome instability.Molecular and cellular biology · 2001Article
- Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p.Nucleic acids research · 2000Article
- Telomere folding is required for the stable maintenance of telomere position effects in yeast.Molecular and cellular biology · 2000Article
- Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro.Nucleic acids research · 2000Article
- High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and human evolution.American journal of human genetics · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In Saccharomyces cerevisiae, proximity to a telomere affects both transcription and replication of adjacent DNA. In this study, we show that telomeres also impose a position effect on mitotic recombination. The rate of recombination between directly repeated tracts of telomeric C1-3A/TG1-3 DNA was reduced severely by proximity to a telomere. In contrast, recombination of two control substrates was not affected by telomere proximity. Thus, unlike position effects on transcription or replication, inhibition of recombination was sequence specific. Moreover, the repression of recombination was not under the same control as transcriptional repression (telomere position effect; TPE), as mutations in genes essential for TPE did not alleviate telomeric repression of recombination. The reduction in recombination between C1-3A/TG1-3 tracts near the telomere was caused by an absence of Rad52p-dependent events as well as a reduction in Rad1p-dependent events. The sequence-specific repression of recombination near the telomere was eliminated in cells that overexpressed the telomere-binding protein Rap1p, a condition that also increased recombination between C1-3A/TG1-3 tracts at internal positions on the chromosome. We propose that the specific inhibition between C1-3A/TG1-3 tracts near the telomere occurs through the action of a telomere-specific end-binding protein that binds to the single-strand TG1-3 tail generated during the processing of recombination intermediates. The recombination inhibitor protein may also block recombination between endogenous telomeres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.