ArticleBritish journal of clinical pharmacology1998
Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children.
Article in British journal of clinical pharmacology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Pharmacokinetics of Oral and Intravenous Paracetamol (Acetaminophen) When Co-Administered with Intravenous Morphine in Healthy Adult Subjects.Clinical drug investigation · 2018Trial
- Successful Use of [Clinical pharmacokinetics · 2017Trial
- Population Pharmacokinetic Modeling of Guanfacine in Pediatric Patients.Clinical pharmacokinetics · 2015Trial
- Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers.European journal of clinical pharmacology · 2005Trial
- Acetaminophen in cerebrospinal fluid in children.European journal of clinical pharmacology · 2003Trial
- Paracetamol and its metabolites in children and adults with spinal muscular atrophy - a population pharmacokinetic model.British journal of clinical pharmacology · 2025Article
- Bioequivalence of a New Pediatric Paracetamol Oral Suspension Compared With a Marketed Formulation in Healthy Adults: A Randomized, Open-Label Study.Current therapeutic research, clinical and experimental · 2024Article
- Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol.iScience · 2023Article
- Optimal Timing of Intravenous Acetaminophen Administration for Postoperative Analgesia.Anesthesia progress · 2022Article
- Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity.Pharmacological research · 2016Review
- Recent Advances in Pediatric Use of Oral Paracetamol in Fever and Pain Management.Pain and therapy · 2015Article
- Understanding the hysteresis loop conundrum in pharmacokinetic/pharmacodynamic relationships.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2014Article
- [Paracetamol for perioperative analgesia. Old substance - new insights].Der Anaesthesist · 2010Article
- Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant.Prostaglandins & other lipid mediators · 2008Article
- Population pharmacokinetic studies in pediatrics: issues in design and analysis.The AAPS journal · 2005Review
- Cerebrospinal fluid pharmacokinetics of paracetamol after intravenous propacetamol in a former preterm infant.British journal of clinical pharmacology · 2004Article
- Nonsteroidal anti-inflammatory agents in neonates.Paediatric drugs · 2003Review
- Modeling of transfer kinetics at the serum-cerebrospinal fluid barrier in rabbits with experimental meningitis: application to grepafloxacin.Antimicrobial agents and chemotherapy · 2003Article
- Efficacies of BMS 284756 against penicillin-sensitive, penicillin-resistant, and quinolone-resistant pneumococci in experimental meningitis.Antimicrobial agents and chemotherapy · 2002Article
- A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and children.British journal of clinical pharmacology · 2000Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsParacetamol has a central action for both antipyresis and analgesia. Maximum temperature decrease and peak analgesia are reported at 1-2 h after peak plasma paracetamol concentration. We wished to determine the relationship between plasma and cerebrospinal fluid (CSF) pharmacokinetics in children.
methodsConcentration-time profiles in plasma and CSF after nasogastric paracetamol 40 mg kg(-1) were measured in nine children who had indwelling ventricular drains. Estimation of population pharmacokinetic parameters was made using both a standard two-stage population approach (MKMODEL) and a nonlinear mixed effect model (NONMEM). Results were standardized to a 70 kg person using an allometric power model.
resultsBoth approaches gave similar estimates. NONMEM parameter estimates were clearance 10.21 h(-1) (CV 47%), volume of distribution 67.11 (CV 58%) and absorption rate constant 0.77 h(-1) (CV 49%). Cerebrospinal fluid concentrations lagged behind those of plasma. The equilibration half time was 0.72 h (CV 117%). The CSF/plasma partition coefficient was 1.18 (CV 8%).
conclusionsHigher concentrations in the CSF probably reflect the lower free water volume of plasma. The CSF equilibration half time suggests that CSF kinetics approximate more closely to the effect compartment than plasma, but further time is required for paracetamol to exert its effects. Effect site concentrations equilibrate slowly with plasma. Paracetamol should be given 1-2 h before anticipated pain or fever in children.
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