ReviewBritish journal of clinical pharmacology1998
Therapeutic drug monitoring--antiepileptic drugs.
Review in British journal of clinical pharmacology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Environmental implications of SiScientific reports · 2025Article
- Article
- Implementation and validation of a 24/7 system for the monitoring of antiepileptic drugs.Frontiers in neurology · 2025Article
- Management of Anti-Seizure Medications during Pregnancy: Advancements in The Past Decade.Pharmaceutics · 2022Review
- Management of Epileptic Seizures in Disorders of Consciousness: An International Survey.Frontiers in neurology · 2021Article
- Potency and plasma protein binding of drugsThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2019Review
- [Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience].The Pan African medical journal · 2016Article
- On the Slow Diffusion of Point-of-Care Systems in Therapeutic Drug Monitoring.Frontiers in bioengineering and biotechnology · 2015Review
- Modern methods for analysis of antiepileptic drugs in the biological fluids for pharmacokinetics, bioequivalence and therapeutic drug monitoring.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2011Article
- Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age.Clinical pharmacokinetics · 2006Review
- Therapeutic drug monitoring of psychotropic medications.British journal of clinical pharmacology · 2000Review
- Therapeutic drug monitoring in a developing country: an overview.British journal of clinical pharmacology · 1999Review
- Target concentration intervention: beyond Y2K.British journal of clinical pharmacology · 1999Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo provide a brief critical review of the basis and contemporary practice of monitoring the concentrations of antiepileptic drugs in biological fluids.
methodsThe review is based on literature data and observations from clinical practice.
resultsAs experience has accumulated, monitoring of antiepileptic drug concentrations has come to be applied mainly to certain of the drugs when present in whole plasma. For these drugs there is a reasonably established relationship between drug concentrations and biological effects, but attention still needs to be paid to issues such as the timing of the measurements in relation to drug intake, the presence or absence of steady-state conditions, the presence in plasma of active metabolites and possible nonlinear pharmacokinetics of particular agents e.g. phenytoin.
conclusionsPlasma antiepileptic drug concentration monitoring is coming to be used in a more thoughtful and critical manner. Lack of adequate knowledge of matters such as the relationship between the plasma concentrations and antiepileptic and toxic effects of the drugs, not only the newer, but also the longer established ones, in particular clinical situations, remains more important than deficiencies in analytical methodology in limiting the clinical usefulness of antiepileptic drug concentration monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.