ArticleClinical and experimental immunology1998
Mercury-induced autoimmunity in the absence of IL-4.
Article in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Mercury-induced inflammation and autoimmunity.Biochimica et biophysica acta. General subjects · 2019Review
- T cell subsets and their signature cytokines in autoimmune and inflammatory diseases.Cytokine · 2015Review
- The role of decay accelerating factor in environmentally induced and idiopathic systemic autoimmune disease.Autoimmune diseases · 2014Review
- Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity.PloS one · 2014Article
- Depletion of complement does not impact initiation of xenobiotic-induced autoimmune disease.Immunology · 2012Article
- Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro.Environmental health perspectives · 2009Article
- Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity.Clinical and experimental immunology · 2009Article
- Interleukin-10 in murine metal-induced systemic autoimmunity.Clinical and experimental immunology · 2005Article
- B7-1 and B7-2 co-stimulatory molecules are required for mercury-induced autoimmunity.Clinical and experimental immunology · 2002Article
- Murine metal-induced systemic autoimmunity: baseline and stimulated cytokine mRNA expression in genetically susceptible and resistant strains.Clinical and experimental immunology · 2001Article
- Cytokine regulation of a rodent model of mercuric chloride-induced autoimmunity.Environmental health perspectives · 1999Review
- Murine mercury-induced autoimmunity: a model of chemically related autoimmunity in humans.Immunologic research · 1999Review
- Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment.Neurotoxicology and teratologyReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In susceptible H-2S mice, mercuric chloride (HgCl2) induces an autoimmune syndrome characterized by production of anti-nucleolar antibodies (ANoA) and increased serum levels of IgG1 and IgE antibodies. The increase in serum IgG1 and IgE, which are under IL-4 control, suggests a role for the Th2 subset in the induction of this syndrome. We have previously shown that administration of IL-12, a potent Th1-promoting cytokine, resulted in a dramatic reduction of the HgCl2-induced anti-nucleolar antibody titres and inhibited serum IgG1 increase. These results suggest that Th1 T cells can down-regulate ANoA, and support a role for the Th2 subset in ANoA production, possibly via IL-4. To examine the role of IL-4 in this syndrome, C57Bl/6 mice (H-2b) with a targeted deletion of the IL-4 gene were mated with A.SW mice (H-2S) to yield H-2S mice lacking IL-4. We then analysed ANoA and serum immunoglobulin levels in these mice after HgCl2 treatment. While mercury-treated IL-4(-/-) H-2S mice had virtually no detectable serum IgG1 or IgE, and very low levels of IgG1 ANoA, these mice had levels of IgG2a and IgG2b class ANoA comparable to mercury-treated IL-4+ H-2S mice, indicating that IL-4 is not required for the ANoA response in mercury-induced autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.