ReviewGut1998
Importance of changes in epithelial cell turnover during Helicobacter pylori infection in gastric carcinogenesis.
Review in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 72 citations in OpenAlex.
- Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication.Journal of gastroenterology · 2009Trial
- Effect of preoperative regional artery chemotherapy on proliferation and apoptosis of gastric carcinoma cells.World journal of gastroenterology · 2002Trial
- Helicobacter pylori VacA modulates TRAF1-mediated 4-1BB/NF-kappaB axis to induce host apoptosis and chronic inflammatory damage.Molecular medicine (Cambridge, Mass.) · 2025Article
- Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Helicobacter pylori protein JHP0290 exhibits proliferative and anti-apoptotic effects in gastric epithelial cells.PloS one · 2015Article
- Disturbance of apoptosis and DNA synthesis by Helicobacter pylori infection of hepatocytes.Digestive diseases and sciences · 2008Article
- Involvement of mast cells in gastritis caused by Helicobacter pylori: a potential role in epithelial cell apoptosis.Journal of clinical pathology · 2007Article
- Extracellular signal-regulated kinase 1- and 2-mediated gastric mucosal injury and repair in gastric ischemia-reperfusion of rats.Journal of gastroenterology · 2006Article
- Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure.World journal of gastroenterology · 2005Article
- Infection with Helicobacter pylori affects all major secretory cell populations in the human antrum.Digestive diseases and sciences · 2005Article
- Gastric mucosal proliferative and total tyrosine kinases activities increase in Helicobacter pylori-induced chronic gastritis.International journal of gastrointestinal cancer · 2005Article
- Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis.World journal of gastroenterology · 2004Article
- Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer.Infection and immunity · 2004Article
- Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism.Infection and immunity · 2002Article
- Detection of H.pylori DNA in gastric epithelial cells by in situ hybridization.World journal of gastroenterology · 2002Article
- p53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer: relation to histological subtypes, Helicobacter pylori infection, and prognosis.Digestive diseases and sciences · 2002Article
- Apoptosis, proliferation and p53 gene expression of H. pylori associated gastric epithelial lesions.World journal of gastroenterology · 2001Article
- Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.Infection and immunity · 2001Article
- No evidence of Helicobacter pylori sequences in pancreatic juices of patients affected by chronic pancreatitis.International journal of pancreatology : official journal of the International Association of Pancreatology · 2000Article
- Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1).Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of Helicobacter pylori in gastric carcinogenesis is supported almost exclusively by epidemiological data and prospective histopathological studies. From biological and molecular points of view, there is no evidence that H pylori or its cytotoxic products have any mutagenic effects. Nevertheless, this infection is associated with profound changes in the pattern of epithelial cell turnover in gastric glands, though the importance of these changes in gastric carcinogenesis is still controversial. H pylori infection increases cell proliferation and alters the distribution of cycling cells within these glands, but these changes can be reversed by successful eradication of the infection. Apoptosis seems to be increased in gastric epithelial cells during H pylori infection, as shown by in vitro studies. There is some, though no conclusive, evidence that this finding also occurs in H pylori positive subjects. It seems that cagA status influences the effect of H pylori on epithelial apoptosis in infected patients. An association of in vitro H pylori induced apoptosis with changes in the expression of pro- and anti-apoptotic genes is reported in the literature, but further study is necessary to clarify the effect of H pylori infection on the molecular events of the apoptotic pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.