ArticleThe Journal of physiology1998
The influence of nerves on the secretion of immunoglobulin A into submandibular saliva in rats.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- Effect of 100 Hz electroacupuncture on salivary immunoglobulin A and the autonomic nervous system.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2015Trial
- SARS-CoV-2 specific sIgA in saliva increases after disease-related video stimulation.Scientific reports · 2023Article
- Slow Breathing Reduces Biomarkers of Stress in Response to a Virtual Reality Active Shooter Training Drill.Healthcare (Basel, Switzerland) · 2023Article
- Immunological Response to Exercise in Athletes with Disabilities: A Narrative Review of the Literature.Healthcare (Basel, Switzerland) · 2023Review
- Disease-related disgust promotes antibody release in human saliva.Brain, behavior, & immunity - health · 2022Article
- Changes in salivary biomarkers associated with periodontitis and diabetic neuropathy in individuals with type 1 diabetes.Scientific reports · 2022Article
- Salivary Proteome Changes in Response to Acute Psychological Stress Due to an Oral Exam Simulation in University Students: Effect of an Olfactory Stimulus.International journal of molecular sciences · 2021Article
- Effect of High Fat and Fructo-Oligosaccharide Consumption on Immunoglobulin A in Saliva and Salivary Glands in Rats.Nutrients · 2021Article
- Using Salivary Biomarkers for Stress Assessment in Offshore Saturation Diving: A Pilot Study.Frontiers in physiology · 2021Article
- Article
- Restoration of Cyclo-Gly-Pro-induced salivary hyposecretion and submandibular composition by naloxone in mice.PloS one · 2020Article
- Rat mesenteric small artery neurogenic dilatation is predominantly mediated by βThe Journal of physiology · 2019Article
- Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain.Journal of dental sciences · 2018Article
- The Salivary IgA Flow Rate Is Increased by High Concentrations of Short-Chain Fatty Acids in the Cecum of Rats Ingesting Fructooligosaccharides.Nutrients · 2016Article
- Dynamic changes in saliva after acute mental stress.Scientific reports · 2014Article
- Role of nonsynaptic communication in regulating the immune response.Neurochemistry international · 2008Review
- Autonomic neurotransmitters modulate immunoglobulin A secretion in porcine colonic mucosa.Journal of neuroimmunology · 2007Article
- Rat salivary gland ligation causes reversible secretory hypofunction.Acta physiologica (Oxford, England) · 2007Article
- Reflex secretion of proteins into submandibular saliva in conscious rats, before and after preganglionic sympathectomy.The Journal of physiology · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The influence of sympathetic and parasympathetic nerve stimulations on salivary secretion of immunoglobulin A (IgA) was studied in the submandibular glands of anaesthetized rats by stimulating the nerve supplies with bipolar electrodes. 2. Although the flow of saliva from sympathetically stimulated glands was only 23% of that from parasympathetically stimulated glands the output of IgA was over 2-fold greater. This difference was attributable to influences of the nerves on IgA secretion through the epithelial cell polymeric immunoglobulin receptor-mediated pathway, as Western blotting with specific antibodies to IgA and secretory component revealed that secretory IgA (SIgA) dominated in all saliva samples. 3. Study of saliva secreted in sequential periods of nerve stimulation or following rest pauses suggested that SIgA secretion occurred in the absence of stimulation but this was upregulated 2.6- and 6-fold by parasympathetic and sympathetic nerve stimulations, respectively, compared with the calculated unstimulated rate. 4. The IgA content of extensively stimulated glands was 77% of levels in unstimulated contralateral control glands despite a secretion into saliva equivalent to almost 90% of the glandular IgA content. The IgA may be synthesized and secreted by glandular plasma cells at a rate which exceeds demand and/or such synthesis may be upregulated by nerve impulses. 5. The results indicate that salivary secretion of SIgA is upregulated by nerve impulses and that sympathetic nerves induce a greater effect than parasympathetic nerves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.