ArticleThe Journal of experimental medicine1998
Regulation of anti-DNA B cells in recombination-activating gene-deficient mice.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 78 citations in OpenAlex.
- B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells.Immunological reviews · 2022Review
- Systemic Lupus Erythematosus: Definitions, Contexts, Conflicts, Enigmas.Frontiers in immunology · 2018Article
- Lupus nephritis: enigmas, conflicting models and an emerging concept.Molecular medicine (Cambridge, Mass.) · 2013Review
- Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity.Seminars in immunopathology · 2013Review
- Central B-cell tolerance: where selection begins.Cold Spring Harbor perspectives in biology · 2012Article
- Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- B cell receptor editing in tolerance and autoimmunity.Annals of the New York Academy of Sciences · 2011Review
- Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Editing and escape from editing in anti-DNA B cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Understanding B-cell tolerance through the use of immunoglobulin transgenic models.Immunologic research · 2008Review
- Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.Molecular immunology · 2007Article
- Article
- The evolution of human anti-double-stranded DNA autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Human autoantibody silencing by immunoglobulin light chains.The Journal of experimental medicine · 2004Article
- Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern.The Journal of experimental medicine · 2002Article
- DNA-dependent protein kinase activity is not required for immunoglobulin class switching.The Journal of experimental medicine · 2002Article
- Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A B-cell receptor-specific selection step governs immature to mature B cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Anti-DNA antibodies are regulated in normal individuals but are found in high concentration in the serum of systemic lupus erythematosus (SLE) patients and the MRL lpr/lpr mouse model of SLE. We previously studied the regulation of anti-double-stranded (ds)DNA and anti-single-stranded (ss)DNA B cells in a nonautoimmune background by generating mice carrying immunoglobulin transgenes coding for anti-DNAs derived from MRL lpr/lpr. Anti-dsDNA B cells undergo receptor editing, but anti-ssDNA B cells seem to be functionally silenced. Here we have investigated how anti-DNA B cells are regulated in recombination- activating gene (RAG)-2-/- mice. In this setting, anti-dsDNA B cells are eliminated by apoptosis in the bone marrow and anti-ssDNA B cells are partially activated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.