ArticleThe Journal of experimental medicine1998
Receptor editing occurs frequently during normal B cell development.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 200 citations in OpenAlex.
- Human genetic variation shapes the antibody repertoire across B cell development.bioRxiv : the preprint server for biology · 2025Article
- Article
- Asymmetrical forward and reverse developmental trajectories determine molecular programs of B cell antigen receptor editing.Science immunology · 2022Article
- A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains.European journal of medical research · 2021Article
- Foxo3 Promotes Apoptosis of B Cell Receptor-Stimulated Immature B Cells, Thus Limiting the Window for Receptor Editing.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Microbial symbionts regulate the primary Ig repertoire.The Journal of experimental medicine · 2018Article
- On being the right size: antibody repertoire formation in the mouse and human.Immunogenetics · 2018Review
- Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire.Frontiers in immunology · 2018Review
- Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.Nature immunology · 2017Article
- Mechanisms of central tolerance for B cells.Nature reviews. Immunology · 2017Review
- Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice.Frontiers in immunology · 2017Article
- VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Primary immunoglobulin repertoire development: time and space matter.Current opinion in immunology · 2015Review
- Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoire.BMC immunology · 2014Article
- Microbial colonization influences early B-lineage development in the gut lamina propria.Nature · 2013Article
- Regulation of VH replacement by B cell receptor-mediated signaling in human immature B cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity.The Journal of experimental medicine · 2013Article
- Secondary mechanisms of diversification in the human antibody repertoire.Frontiers in immunology · 2013Article
- Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Allelic exclusion is established in development through a feedback mechanism in which the assembled immunoglobulin (Ig) suppresses further V(D)J rearrangement. But Ig expression sometimes fails to prevent further rearrangement. In autoantibody transgenic mice, reactivity of immature B cells with autoantigen can induce receptor editing, in which allelic exclusion is transiently prevented or reversed through nested light chain gene rearrangement, often resulting in altered B cell receptor specificity. To determine the extent of receptor editing in a normal, non-Ig transgenic immune system, we took advantage of the fact that lambda light chain genes usually rearrange after kappa genes. This allowed us to analyze kappa loci in IgMlambda+ cells to determine how frequently in-frame kappa genes fail to suppress lambda gene rearrangements. To do this, we analyzed recombined VkappaJkappa genes inactivated by subsequent recombining sequence (RS) rearrangement. RS rearrangements delete portions of the kappa locus by a V(D)J recombinase-dependent mechanism, suggesting that they play a role in receptor editing. We show that RS recombination is frequently induced by, and inactivates, functionally rearranged kappa loci, as nearly half (47%) of the RS-inactivated VkappaJkappa joins were in-frame. These findings suggest that receptor editing occurs at a surprisingly high frequency in normal B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.