ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Autocrine hepatocyte growth factor provides a local mechanism for promoting axonal growth.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Gene therapy for diabetic peripheral neuropathy: A randomized, placebo-controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor.Clinical and translational science · 2021Trial
- Phase 1/2 open-label dose-escalation study of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with painful diabetic peripheral neuropathy.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Trial
- Advanced Gene-Targeting Therapies for Motor Neuron Diseases and Muscular Dystrophies.International journal of molecular sciences · 2022Review
- The sympathetic nervous system in development and disease.Nature reviews. Neuroscience · 2021Review
- Efficacy of nonviral gene transfer of human hepatocyte growth factor (HGF) against ischemic-reperfusion nerve injury in rats.PloS one · 2020Article
- Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation.Neural development · 2016Article
- Double-blind, placebo-controlled study of HGF gene therapy in diabetic neuropathy.Annals of clinical and translational neurology · 2015Article
- New and developing drugs for the treatment of neuropathic pain in diabetes.Current diabetes reports · 2013Review
- MET receptor tyrosine kinase as an autism genetic risk factor.International review of neurobiology · 2013Review
- The N-glycanase png-1 acts to limit axon branching during organ formation in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Production of compartmented cultures of rat sympathetic neurons.Nature protocols · 2009Article
- NGF-promoted axon growth and target innervation requires GITRL-GITR signaling.Nature neuroscience · 2008Article
- Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- An activity-dependent neurotrophin-3 autocrine loop regulates the phenotype of developing hippocampal pyramidal neurons before target contact.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Article
- Induction of the plasminogen activator system accompanies peripheral nerve regeneration after sciatic nerve crush.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crush.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this report, we describe a novel local mechanism necessary for optimal axonal growth that involves hepatocyte growth factor (HGF). Sympathetic neurons of the superior cervical ganglion coexpress bioactive HGF and its receptor, the Met tyrosine kinase, both in vivo and in vitro. Exogenous HGF selectively promotes the growth but not survival of cultured sympathetic neurons; the magnitude of this growth effect is similar to that observed with exogenous NGF. Conversely, HGF antibodies that inhibit endogenous HGF decrease sympathetic neuron growth but have no effect on survival. This autocrine HGF is required locally by sympathetic axons for optimal growth, as demonstrated using compartmented cultures. Thus, autocrine HGF provides a local, intrinsic mechanism for promoting neuronal growth without affecting survival, a role that may be essential during developmental axogenesis or after neuronal injury.
Indexed as
Identifiers
9763480PMC6792841What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.