ArticleMolecular biology of the cell1998
Coilin can form a complex with the U7 small nuclear ribonucleoprotein.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- A Novel Role for Coilin in Vertebrate Innate Immunity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Cajal body formation is regulated by coilin SUMOylation.Journal of cell science · 2024Article
- Coilin mediates m6A RNA methylation through phosphorylation of METTL3.Biology open · 2023Article
- Coilin and Cajal bodies.Nucleus (Austin, Tex.) · 2023Review
- The 3' Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies' association with histone locus bodies.Nature communications · 2022Article
- Specific genomic cues regulate Cajal body assembly.RNA biology · 2017Review
- Coilin: The first 25 years.RNA biology · 2015Review
- Article
- Coilin displays differential affinity for specific RNAs in vivo and is linked to telomerase RNA biogenesis.Journal of molecular biology · 2013Article
- The abbreviated pluripotent cell cycle.Journal of cellular physiology · 2013Review
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- Pearls are novel Cajal body-like structures in the Xenopus germinal vesicle that are dependent on RNA pol III transcription.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing.PloS one · 2012Article
- The architectural organization of human stem cell cycle regulatory machinery.Current pharmaceutical design · 2012Review
- The Cajal body and histone locus body.Cold Spring Harbor perspectives in biology · 2010Review
- Genetic analysis of nuclear bodies: from nondeterministic chaos to deterministic order.Cold Spring Harbor symposia on quantitative biology · 2010Article
- Small Cajal body-specific RNAs of Drosophila function in the absence of Cajal bodies.Molecular biology of the cell · 2009Article
- Coilin is essential for Cajal body organization in Drosophila melanogaster.Molecular biology of the cell · 2009Article
- Chromosome odds and ends.Annual review of cell and developmental biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Coiled bodies (CBs) in the amphibian oocyte nucleus are spherical structures up to 10 microm or more in diameter, much larger than their somatic counterparts, which rarely exceed 1 microm. Oocyte CBs may have smaller granules attached to their surface or embedded within them, which are identical in structure and composition to the many hundreds of B-snurposomes found free in the nucleoplasm. The matrix of the CBs contains the diagnostic protein p80-coilin, which is colocalized with the U7 small nuclear ribonucleoprotein (snRNP), whereas the attached and embedded B-snurposomes contain splicing snRNPs. A few of the 50-100 CBs in the oocyte nucleus are attached to lampbrush chromosomes at the histone gene loci. By coimmunoprecipitation we show that coilin and the U7 snRNP can form a weak but specific complex in the nucleoplasm, which is dependent on the special U7 Sm-binding site. Under the same conditions coilin does not associate with the U1 and U2 snRNPs. Coilin is a nucleic acid-binding protein, as shown by its interaction with single-stranded DNA and with poly r(U) and poly r(G). We suggest that an important function of coilin is to form a transient complex with the U7 snRNP and accompany it to the CBs. In the case of CBs attached to chromosomes at the histone gene loci, the U7 snRNP is thus brought close to the actual site of histone pre-mRNA transcription.
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Registered trials
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