ArticleMolecular biology of the cell1998
Nucleolar localization elements of Xenopus laevis U3 small nucleolar RNA.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- RNA modification in Cajal bodies.RNA biology · 2017Review
- A weak C' box renders U3 snoRNA levels dependent on hU3-55K binding.Molecular and cellular biology · 2011Article
- NLS peptide conjugated molecular beacons for visualizing nuclear RNA in living cells.Bioconjugate chemistry · 2008Article
- Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.Molecular and cellular biology · 2008Article
- An evolutionary intra-molecular shift in the preferred U3 snoRNA binding site on pre-ribosomal RNA.Nucleic acids research · 2005Article
- Role of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNP.Molecular and cellular biology · 2004Article
- Xenopus U3 snoRNA docks on pre-rRNA through a novel base-pairing interaction.RNA (New York, N.Y.) · 2004Article
- A structural, phylogenetic, and functional study of 15.5-kD/Snu13 protein binding on U3 small nucleolar RNA.RNA (New York, N.Y.) · 2003Article
- Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP.Molecular and cellular biology · 2002Article
- Naf1p, an essential nucleoplasmic factor specifically required for accumulation of box H/ACA small nucleolar RNPs.Molecular and cellular biology · 2002Article
- All small nuclear RNAs (snRNAs) of the [U4/U6.U5] Tri-snRNP localize to nucleoli; Identification of the nucleolar localization element of U6 snRNA.Molecular biology of the cell · 2002Article
- Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin.Gene expression · 2002Review
- A well-connected and conserved nucleoplasmic helicase is required for production of box C/D and H/ACA snoRNAs and localization of snoRNP proteins.Molecular and cellular biology · 2001Article
- Xenopus U3 snoRNA GAC-Box A' and Box A sequences play distinct functional roles in rRNA processing.Molecular and cellular biology · 2001Article
- An unexpected, conserved element of the U3 snoRNA is required for Mpp10p association.RNA (New York, N.Y.) · 2001Article
- Fluorescent RNA cytochemistry: tracking gene transcripts in living cells.Nucleic acids research · 2001Review
- The 28S-18S rDNA intergenic spacer from Crithidia fasciculata: repeated sequences, length heterogeneity, putative processing sites and potential interactions between U3 small nucleolar RNA and the ribosomal RNA precursor.Nucleic acids research · 2000Article
- Interaction of the U3-55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3-55k.Nucleic acids research · 2000Article
- Transient nucleolar localization Of U6 small nuclear RNA in Xenopus Laevis oocytes.Molecular biology of the cell · 2000Article
- Multiple conserved segments of E1 small nucleolar RNA are involved in the formation of a ribonucleoprotein particle in frog oocytes.The Biochemical journal · 2000Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The Nucleolar Localization Elements (NoLEs) of Xenopus laevis U3 small nucleolar RNA (snoRNA) have been defined. Fluorescein-labeled wild-type U3 snoRNA injected into Xenopus oocyte nuclei localized specifically to nucleoli as shown by fluorescence microscopy. Injection of mutated U3 snoRNA revealed that the 5' region containing Boxes A and A', known to be important for rRNA processing, is not essential for nucleolar localization. Nucleolar localization of U3 snoRNA was independent of the presence and nature of the 5' cap and the terminal stem. In contrast, Boxes C and D, common to the Box C/D snoRNA family, are critical elements for U3 localization. Mutation of the hinge region, Box B, or Box C' led to reduced U3 nucleolar localization. Results of competition experiments suggested that Boxes C and D act in a cooperative manner. It is proposed that Box B facilitates U3 snoRNA nucleolar localization by the primary NoLEs (Boxes C and D), with the hinge region of U3 subsequently base pairing to the external transcribed spacer of pre-rRNA, thus positioning U3 snoRNA for its roles in rRNA processing.
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