ArticleMolecular biology of the cell1998
A yeast t-SNARE involved in endocytosis.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 90 citations in OpenAlex.
- The yeast endocytic early/sorting compartment exists as an independent sub-compartment within theeLife · 2023Article
- SNARE complex in axonal guidance and neuroregeneration.Neural regeneration research · 2018Review
- Budding Yeast Has a Minimal Endomembrane System.Developmental cell · 2018Article
- Atg27 tyrosine sorting motif is important for its trafficking and Atg9 localization.Traffic (Copenhagen, Denmark) · 2015Article
- Qa-SNAREs localized to the trans-Golgi network regulate multiple transport pathways and extracellular disease resistance in plants.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A novel function for SNAP29 (synaptosomal-associated protein of 29 kDa) in mast cell phagocytosis.PloS one · 2012Article
- Mutational analysis of the yeast TRAPP subunit Trs20p identifies roles in endocytic recycling and sporulation.PloS one · 2012Article
- Prm1 targeting to contact sites enhances fusion during mating in Saccharomyces cerevisiae.Eukaryotic cell · 2010Article
- Ultrastructural analysis of nanogold-labeled endocytic compartments of yeast Saccharomyces cerevisiae using a cryosectioning procedure.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Functional homology of mammalian syntaxin 16 and yeast Tlg2p reveals a conserved regulatory mechanism.Journal of cell science · 2009Article
- Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER.Journal of cell science · 2009Article
- A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.The Journal of biological chemistry · 2008Article
- Rtn1p is involved in structuring the cortical endoplasmic reticulum.Molecular biology of the cell · 2006Article
- The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes.The Journal of cell biology · 2006Article
- The Gcs1 Arf-GAP mediates Snc1,2 v-SNARE retrieval to the Golgi in yeast.Molecular biology of the cell · 2006Article
- Arf1p, Chs5p and the ChAPs are required for export of specialized cargo from the Golgi.The EMBO journal · 2006Article
- Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p.Eukaryotic cell · 2005Article
- Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae.Molecular biology of the cell · 2004Article
- Dual prenylation is required for Rab protein localization and function.Molecular biology of the cell · 2003Article
- Cdc50p, a conserved endosomal membrane protein, controls polarized growth in Saccharomyces cerevisiae.Molecular biology of the cell · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ORF YOL018c (TLG2) of Saccharomyces cerevisiae encodes a protein that belongs to the syntaxin protein family. The proteins of this family, t-SNAREs, are present on target organelles and are thought to participate in the specific interaction between vesicles and acceptor membranes in intracellular membrane trafficking. TLG2 is not an essential gene, and its deletion does not cause defects in the secretory pathway. However, its deletion in cells lacking the vacuolar ATPase subunit Vma2p leads to loss of viability, suggesting that Tlg2p is involved in endocytosis. In tlg2Delta cells, internalization was normal for two endocytic markers, the pheromone alpha-factor and the plasma membrane uracil permease. In contrast, degradation of alpha-factor and uracil permease was delayed in tlg2Delta cells. Internalization of positively charged Nanogold shows that the endocytic pathway is perturbed in the mutant, which accumulates Nanogold in primary endocytic vesicles and shows a greatly reduced complement of early endosomes. These results strongly suggest that Tlg2p is a t-SNARE involved in early endosome biogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.