ArticleThe Biochemical journal1998
Sialomucin complex at the rat ocular surface: a new model for ocular surface protection.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 63 citations in OpenAlex.
- Ocular surface glycocalyx in health and disease.Frontiers in cell and developmental biology · 2025Review
- Human ocular mucins: The endowed guardians of sight.Advanced drug delivery reviews · 2022Review
- Membrane-associated mucins of the ocular surface: New genes, new protein functions and new biological roles in human and mouse.Progress in retinal and eye research · 2020Review
- Membrane-tethered mucins have multiple functions on the ocular surface.Experimental eye research · 2010Review
- Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF-beta.Journal of cellular physiology · 2010Article
- Muc4/MUC4 functions and regulation in cancer.Future oncology (London, England) · 2009Review
- Examination of the restoration of epithelial barrier function following superficial keratectomy.Experimental eye research · 2007Article
- [Lacrimal gland-associated mucins. Age related production and their role in the pathophysiology of dry eye].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2005Review
- Human preocular mucins reflect changes in surface physiology.The British journal of ophthalmology · 2004Article
- Synthesis and secretion of Muc4/sialomucin complex: implication of intracellular proteolysis.The Biochemical journal · 2002Article
- Article
- Muc4/sialomucin complex in the mammary gland and breast cancer.Journal of mammary gland biology and neoplasia · 2001Review
- Cloning and characterization of the 5' flanking region of the sialomucin complex/rat Muc4 gene: promoter activity in cultured cells.The Biochemical journal · 2000Article
- The tear film and ocular mucins.Veterinary ophthalmologyReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The ocular surface, which is among the most accessible and vulnerable tissues in mammals, is protected by a complex tear film composed of lipid, aqueous and mucin layers. In spite of its importance, the molecular nature of the mucin contribution remains uncertain. Since membrane mucins have been implicated in the protection of other epithelia, we have analysed rat corneal and conjunctival tissues for sialomucin complex (SMC), a membrane mucin found at the apical epithelial cell surfaces in the airway and uterus. Using Northern and Western blot analyses, SMC expression was found in both ocular tissues, being particularly abundant in the cornea. In contrast with the other known membrane mucin, MUC1, SMC was localized more heavily towards the apical surface of the epithelial cells. SMC in ocular surface epithelia was produced in both soluble and membrane forms, the latter being found predominantly in the most superficial cells and at apical surfaces. The soluble form was found loosely adsorbed to apical cell surfaces, particularly of the cornea, as indicated by a mild rinsing protocol. Finally, the tear fluid contained substantial amounts of SMC. From these results, we propose a new model for tear mucin components in which SMC is expressed at the apical ocular surface in both membrane-bound and adsorbed soluble forms to provide a direct protective barrier. SMC secreted into the tear fluid may also participate in maintaining the stability of the preocular tear film by acting with other secreted mucins to determine the physical properties and protective behaviour of the tear film.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.