ArticleProtein science : a publication of the Protein Society1998
Uclacyanins, stellacyanins, and plantacyanins are distinct subfamilies of phytocyanins: plant-specific mononuclear blue copper proteins.
Article in Protein science : a publication of the Protein Society, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 175 citations in OpenAlex.
- miR408-5p and miR408-3p cooperatively reduce cadmium uptake and accumulation in rice.PLoS biology · 2026Article
- Structural basis for organism-dependent effects on spectroscopic properties of type 1 copper azurin by the same axial methionine to histidine mutation.Journal of inorganic biochemistry · 2026Article
- Comprehensive genomic and haplotype analysis of the phytocyanin gene family reveals evolutionary expansion and functional diversification in Setaria italica.Plant cell reports · 2026Article
- Uclacyanin MtUC1 Is Involved in the Regulation of Nodule Senescence in Medicago truncatula.Molecular plant pathology · 2025Article
- Beyond Blue: Systematic Modulation of Electronic Structure and Redox Properties of Type 1 Copper in Azurin.Journal of the American Chemical Society · 2025Article
- Genetic Dissection of ToLCNDV Resistance in Resistant Sources ofInternational journal of molecular sciences · 2024Article
- Molecular evolution of Phytocyanin gene and analysis of expression at different coloring periods in apple (Malus domestica).BMC plant biology · 2024Article
- Decrypting Molecular Mechanisms Involved in Counteracting Copper and Nickel Toxicity in Jack Pine (Plants (Basel, Switzerland) · 2024Article
- Cytological observation and RNA-seq analysis reveal novel miRNAs high expression associated with the pollen fertility of neo-tetraploid rice.BMC plant biology · 2023Article
- The miR408a-BBP-LAC3/CSD1 module regulates anthocyanin biosynthesis mediated by crosstalk between copper homeostasis and ROS homeostasis during light induction in Malus plants.Journal of advanced research · 2023Article
- Tuning the Type 1 Reduction Potential of Multicopper Oxidases: Uncoupling the Effects of Electrostatics and H-Bonding to Histidine Ligands.Journal of the American Chemical Society · 2023Article
- Article
- Phytocyanin-encoding genes confer enhanced ozone tolerance in Arabidopsis thaliana.Scientific reports · 2022Article
- Orchestrating copper binding: structure and variations on the cupredoxin fold.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Review
- Designing Artificial Metalloenzymes by Tuning of the Environment beyond the Primary Coordination Sphere.Chemical reviews · 2022Review
- The Evolution and Functional Roles ofInternational journal of molecular sciences · 2022Review
- The PIF1-miR408-PLANTACYANIN repression cascade regulates light-dependent seed germination.The Plant cell · 2021Article
- Review
- High-order mutants reveal an essential requirement for peroxidases but not laccases in Casparian strip lignification.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Copper deficiency alters shoot architecture and reduces fertility of both gynoecium and androecium inPlant direct · 2020Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The cDNAs encoding plantacyanin from spinach were isolated and characterized. In addition, four new cDNA sequences from Arabidopsis ESTs were identified that encode polypeptides resembling phytocyanins, plant-specific proteins constituting a distinct family of mononuclear blue copper proteins. One of them encodes plantacyanin from Arabidopsis, while three others, designated as uclacyanin 1, 2, and 3, encode protein precursors that are closely related to precursors of stellacyanins and a blue copper protein from pea pods. Comparative analyses with known phytocyanins allow further classification of these proteins into three distinct subfamilies designated as uclacyanins, stellacyanins, and plantacyanins. This specification is based on (1) their spectroscopic properties, (2) their glycosylation state, (3) the domain organization of their precursors, and (4) their copper-binding amino acids. The recombinant copper binding domain of Arabidopsis uclacyanin 1 was expressed, purified, and shown to bind a copper atom in a fashion known as "blue" or type 1. The mutant of cucumber stellacyanin in which the glutamine axial ligand was substituted by a methionine (Q99M) was purified and shown to possess spectroscopic properties similar to uclacyanin 1 rather than to plantacyanins. Its redox potential was determined by cyclic voltammetry to be +420 mV, a value that is significantly higher than that determined for the wild-type protein (+260 mV). The available structural data suggest that stellacyanins (and possibly other phytocyanins) might not be diffusible electron-transfer proteins participating in long-range electron-transfer processes. Conceivably, they are involved in redox reactions occurring during primary defense responses in plants and/or in lignin formation.
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