ArticleAmerican journal of human genetics1998
Childhood absence epilepsy with tonic-clonic seizures and electroencephalogram 3-4-Hz spike and multispike-slow wave complexes: linkage to chromosome 8q24.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 132 citations in OpenAlex.
- Closed-loop controller based on reference signal tracking for absence seizures.Scientific reports · 2022Article
- Consolidating and Upscaling Molecular Research Capacity in Nigeria: On Who's Account?Frontiers in research metrics and analytics · 2021Review
- Stimulus-induced transitions between spike-wave discharges and spindles with the modulation of thalamic reticular nucleus.Journal of computational neuroscience · 2017Article
- Microbial Proteins as Novel Industrial Biotechnology Hosts to Treat Epilepsy.Molecular neurobiology · 2017Review
- Combined Effects of Feedforward Inhibition and Excitation in Thalamocortical Circuit on the Transitions of Epileptic Seizures.Frontiers in computational neuroscience · 2017Article
- Genetic and epigenetic mechanisms of epilepsy: a review.Neuropsychiatric disease and treatment · 2017Review
- Stimulus-induced Epileptic Spike-Wave Discharges in Thalamocortical Model with Disinhibition.Scientific reports · 2016Article
- Disinhibition-induced transitions between absence and tonic-clonic epileptic seizures.Scientific reports · 2015Article
- Article
- An association analysis of reelin gene (RELN) polymorphisms with childhood epilepsy in eastern Indian population from West Bengal.Cellular and molecular neurobiology · 2011Article
- Confirmation of multiple seizure susceptibility QTLs on chromosome 15 in C57BL/6J and DBA/2J inbred mice.Physiological genomics · 2010Article
- Genome wide high density SNP-based linkage analysis of childhood absence epilepsy identifies a susceptibility locus on chromosome 3p23-p14.Epilepsy research · 2009Article
- Genetic basis in epilepsies caused by malformations of cortical development and in those with structurally normal brain.Human genetics · 2009Review
- Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy.American journal of human genetics · 2008Article
- Linkage and association analysis of CACNG3 in childhood absence epilepsy.European journal of human genetics : EJHG · 2007Article
- A TASK3 channel (KCNK9) mutation in a genetic model of absence epilepsy.Journal of molecular neuroscience : MN · 2005Article
- Convulsive disorder and genetic polymorphism. Association of idiopathic generalized epilepsy with haptoglobin polymorphism.Neurogenetics · 2004Article
- Long-term prognosis for childhood and juvenile absence epilepsy.Journal of neurology · 2004Article
- Four new families with autosomal dominant partial epilepsy with auditory features: clinical description and linkage to chromosome 10q24.Epilepsia · 2002Article
- Genetics of inherited human epilepsies.Dialogues in clinical neuroscience · 2001Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
Abstract
Childhood absence epilepsy (CAE), a common form of idiopathic generalized epilepsy, accounts for 5%-15% of childhood epilepsies. To map the chromosomal locus of persisting CAE, we studied the clinical and electroencephalographic traits of 78 members of a five-generation family from Bombay, India. The model-free affected-pedigree member method was used during initial screening with chromosome 6p, 8q, and 1p microsatellites, and only individuals with absence seizures and/or electroencephalogram 3-4-Hz spike- and multispike-slow wave complexes were considered to be affected. Significant P values of .00000-.02 for several markers on 8q were obtained. Two-point linkage analysis, assuming autosomal dominant inheritance with 50% penetrance, yielded a maximum LOD score (Zmax) of 3.6 for D8S502. No other locus in the genome achieved a significant Zmax. For five smaller multiplex families, summed Zmax was 2.4 for D8S537 and 1.7 for D8S1761. Haplotypes composed of the same 8q24 microsatellites segregated with affected members of the large family from India and with all five smaller families. Recombinations positioned the CAE gene in a 3.2-cM interval.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.