ArticleAmerican journal of human genetics1998
Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00091871 (A Longitudinal Study of Familial Hypereosinophilia), which is not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression
Who cites it
31 citing papers in PubMed, 126 citations in OpenAlex.
- A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).Proceedings of the National Academy of Sciences of the United States of America · 2000Trial
- Causal effects of maternal BMI on pregnancy outcomes: a Mendelian randomisation study investigating the mediating role of blood counts.Frontiers in genetics · 2026Article
- Unique Presentation of Postpartum Hypereosinophilic Syndrome With Atypical Features and Therapeutic Challenges.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025Article
- Hypereosinophilia in Children.Current allergy and asthma reports · 2025Review
- Clinical and Therapeutic Intervention of Hypereosinophilia in the Era of Molecular Diagnosis.Cancers · 2024Review
- Diagnosis and Novel Approaches to the Treatment of Hypereosinophilic Syndromes.Current hematologic malignancy reports · 2018Review
- A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia.Leukemia research reports · 2018Article
- Article
- Hypereosinophilic Syndrome.Clinical reviews in allergy & immunology · 2016Review
- The Eosinophil in Health and Disease: from Bench to Bedside and Back.Clinical reviews in allergy & immunology · 2016Review
- Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature.Case reports in medicine · 2016Article
- How I treat hypereosinophilic syndromes.Blood · 2015Review
- Eosinophilic bronchitis, eosinophilia associated genetic variants, and notch signaling in asthma.Allergy, asthma & immunology research · 2010Article
- Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.European journal of human genetics : EJHG · 2010Article
- Recent advances in the characterization of genetic factors involved in human susceptibility to infection by schistosomiasis.Current genomics · 2008Article
- A locus for eosinophilia in the MES rat is on Chromosome 19.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension.American journal of human genetics · 2005Article
- Gene polymorphisms within the immune system that may underlie drug allergy.Naunyn-Schmiedeberg's archives of pharmacology · 2004Review
- Novel association suggests multiple independent QTLs within chromosome 5q21-33 region control variation in total humans IgE levels.Genes and immunity · 2003Article
- Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients.Journal of human genetics · 2003Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Familial eosinophilia (FE) is an autosomal dominant disorder characterized by peripheral hypereosinophilia of unidentifiable cause with or without other organ involvement. To localize the gene for FE, we performed a genomewide search in a large U.S. kindred, using 312 different polymorphic markers. Seventeen affected subjects, 28 unaffected bloodline relatives, and 8 spouses were genotyped. The initial linkage results from the genome scan provided evidence for linkage on chromosome 5q31-q33. Additional genotyping of genetic markers located in this specific region demonstrated significant evidence that the FE locus is situated between the chromosome 5q markers D5S642 and D5S816 (multipoint LOD score of 6.49). Notably, this region contains the cytokine gene cluster, which includes three genes-namely, those for interleukin (IL)-3, IL-5, and granulocyte/macrophage colony-stimulating factor (GM-CSF)-whose products play important roles in the development and proliferation of eosinophils. These three cytokine genes were screened for potential disease-specific mutations by resequencing of a subgroup of individuals from the present kindred. No functional sequence polymorphisms were found within the promoter, the exons, or the introns of any of these genes or within the IL-3/GM-CSF enhancer, suggesting that the primary defect in FE is not caused by a mutation in any one of these genes but, rather, is caused by another gene in the area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.