ArticleAmerican journal of human genetics1998
Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 143 citations in OpenAlex.
- Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese.Behavioral and brain functions : BBF · 2010Trial
- Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families.Molecular psychiatry · 2005Trial
- Genetic Variants from Large Cohorts and Familial Studies Implicate Common Mechanisms in Schizophrenia.Biology · 2026Review
- Nicotine Exposure in a Phencyclidine-Induced Mice Model of Schizophrenia: Sex-Selective Medial Prefrontal Cortex Protein Markers of the Combined Insults in Adolescent Mice.International journal of molecular sciences · 2023Article
- Review
- A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia.Journal of cellular and molecular medicine · 2017Article
- Chromosome 18p11.2 harbors susceptibility marker: D18S452, for bipolar affective disorder.Indian journal of psychiatry · 2013Article
- Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia.Epigenetics · 2013Article
- Genome-wide expression profiling of schizophrenia using a large combined cohort.Molecular psychiatry · 2013Article
- Adenosine hypothesis of schizophrenia--opportunities for pharmacotherapy.Neuropharmacology · 2012Review
- Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14.American journal of physiology. Cell physiology · 2012Article
- Modulators of nucleoside metabolism in the therapy of brain diseases.Current topics in medicinal chemistry · 2011Review
- Identification of a specific assembly of the g protein golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatum.Frontiers in neuroanatomy · 2011Article
- Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.Schizophrenia research · 2009Article
- Investigation of the G protein subunit Galphaolf gene (GNAL) in attention deficit/hyperactivity disorder.Journal of psychiatric research · 2008Article
- TGFB-induced factor (TGIF): a candidate gene for psychosis on chromosome 18p.Molecular psychiatry · 2007Article
- The psychopathology and treatment of bipolar disorder.Annual review of clinical psychology · 2006Review
- Alternative transcripts and evidence of imprinting of GNAL on 18p11.2.Molecular psychiatry · 2005Article
- Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.American journal of human genetics · 2004Article
- Genetics of major mood disorders.Psychiatry (Edgmont (Pa. : Township)) · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The action of antipsychotic drugs on dopamine receptors suggests that dopaminergic signal transmission may play a role in the development of schizophrenia. We tested eight candidate genes (coding for dopamine receptors, the dopamine transporter, and G-proteins) in 59 families from Germany and Israel, for association. A P value of .00055 (.0044 when corrected for the no. of markers tested) was obtained for the intronic CA-repeat marker G-olfalpha on chromosome 18p. The value decreased to .000088 (.0007) when nine sibs with recurrent unipolar depressive disorder were included. Linkage analysis using SSLP markers densely spaced around G-olfalpha yielded a maximum two-point LOD score of 3.1 for a marker 0.5 cM distal to G-olfalpha. Multipoint analysis under the assumption of heterogeneity supported this linkage-whether the affected pheotype was defined narrowly or broadly-as did nonparametric linkage (NPL). In 12 families with exclusively maternal transmission of the disease, the NPL value also supported linkage to this marker. In order to test for association/linkage disequilibrium in the presence of linkage, the sample was restricted to independent offspring. When this sample was combined with 65 additional simplex families (each of them comprising one schizophrenic offspring and his or her parents), the 124-bp allele of G-olfalpha was transmitted 47 times and was not transmitted 21 times (P=.009). These results suggest the existence, on chromosome 18p, of a potential susceptibility locus for functional psychoses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.