ReviewJournal of bioenergetics and biomembranes1998
Structures and functions of calcium channel beta subunits.
Review in Journal of bioenergetics and biomembranes, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 223 citations in OpenAlex.
- Calcium and arrhythmogenesis.Physiological reviews · 2007Pooled it
- CaMKII clusters neuronal LTCCs in biomolecular condensates to gate excitation-transcription coupling.bioRxiv : the preprint server for biology · 2025Article
- Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias.The Journal of innovations in cardiac rhythm management · 2019Review
- Identification and Analysis of Alzheimer's Candidate Genes by an Amplitude Deviation Algorithm.Journal of Alzheimer's disease & Parkinsonism · 2019Article
- Cross talk between β subunits, intracellular CaPhysiological reports · 2018Article
- The HOOK region of β subunits controls gating of voltage-gated CaChannels (Austin, Tex.) · 2017Article
- The HOOK region of voltage-gated Ca2+ channel β subunits senses and transmits PIP2 signals to the gate.The Journal of general physiology · 2017Article
- Expression of Calcium Channel Subunit Variants in Small Mesenteric Arteries of WKY and SHR.American journal of hypertension · 2015Article
- Microdomain-specific localization of functional ion channels in cardiomyocytes: an emerging concept of local regulation and remodelling.Biophysical reviews · 2015Article
- 14-3-3τ promotes surface expression of Cav2.2 (α1B) Ca2+ channels.The Journal of biological chemistry · 2015Article
- Aldosterone and vascular mineralocorticoid receptors: regulators of ion channels beyond the kidney.Hypertension (Dallas, Tex. : 1979) · 2014Review
- Modulation of voltage-gated Ca2+ channels in rat retinal ganglion cells by gabapentin.Visual neuroscience · 2014Article
- The Ca2+ channel β2 subunit is selectively targeted to the axon terminals of supraoptic neurons.Channels (Austin, Tex.) · 2014Article
- Rare mutations of CACNB2 found in autism spectrum disease-affected families alter calcium channel function.PloS one · 2014Article
- Structure and function of the β subunit of voltage-gated Ca²⁺ channels.Biochimica et biophysica acta · 2013Review
- Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches.Pharmacological research · 2013Review
- Mechanical regulation of native and the recombinant calcium channel.Cell calcium · 2013Article
- Review
- Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes.The Journal of physiology · 2011Article
- Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity.Journal of muscle research and cell motility · 2011Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Calcium channel beta subunits have profound effects on how alpha1 subunits perform. In this article we summarize our present knowledge of the primary structures of beta subunits as deduced from cDNAs and illustrate their different properties. Upon co-expression with alpha1 subunits, the effects of beta subunits vary somewhat between L-type and non-L-type channels mostly because the two types of channels have different responses to voltage which are affected by beta subunits, such as long-lasting prepulse facilitation of alpha1C (absent in alpha1E) and inhibition by G protein betagamma dimer of alpha1E, absent in alpha1C. One beta subunit, a brain beta2a splice variant that is palmitoylated, has several effects not seen with any of the others, and these are due to palmitoylation. We also illustrate the finding that functional expression of alpha1 in oocytes requires a beta subunit even if the final channel shows no evidence for its presence. We propose two structural models for Ca2+ channels to account for "alpha1 alone" channels seen in cells with limited beta subunit expression. In one model, beta dissociates from the mature alpha1 after proper folding and membrane insertion. Regulated channels seen upon co-expression of high levels of beta would then have subunit composition alpha1beta. In the other model, the "chaperoning" beta remains associated with the mature channel and "alpha1 alone" channels would in fact be alpha1beta channels. Upon co-expression of high levels of beta the regulated channels would have composition [alpha1beta]beta.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.