ArticleAntimicrobial agents and chemotherapy1998
Rifampin concentrations in various compartments of the human brain: a novel method for determining drug levels in the cerebral extracellular space.
Article in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Adjunctive rifampin for the treatment of Staphylococcus aureus bacteremia with deep infections: A meta-analysis.PloS one · 2020Pooled it
- Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial.The Lancet. Neurology · 2014Trial
- Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study.Journal of neuro-oncology · 2009Trial
- Intracranial infections ofFrontiers in immunology · 2025Review
- A physiologically-based pharmacokinetic model for tuberculosis drug disposition at extrapulmonary sites.CPT: pharmacometrics & systems pharmacology · 2023Article
- Population Pharmacokinetic Analysis of Rifampicin in Plasma, Cerebrospinal Fluid, and Brain Extracellular Fluid in South African Children with Tuberculous Meningitis.Antimicrobial agents and chemotherapy · 2023Article
- Epidural intracranial abscesses and multiple bone metastases caused by disseminated Mycobacterium avium complex infection: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- GCMM: graph convolution network based on multimodal attention mechanism for drug repurposing.BMC bioinformatics · 2022Article
- Article
- The potential of microdialysis to estimate rifampicin concentrations in the lung of guinea pigs.PloS one · 2021Article
- Tuberculous Meningitis in Children and Adults: New Insights for an Ancient Foe.Current neurology and neuroscience reports · 2017Review
- Utility of Microdialysis in Infectious Disease Drug Development and Dose Optimization.The AAPS journal · 2017Review
- CNS Manifestations in Orientia tsutsugamushi Disease (Scrub Typhus) in North India.Indian journal of pediatrics · 2016Article
- Naegleria fowleri: pathogenesis, diagnosis, and treatment options.Antimicrobial agents and chemotherapy · 2015Review
- Intracranial abscess due to Mycobacterium avium complex in an immunocompetent host: a case report.BMC infectious diseases · 2015Article
- Scrub typhus meningitis or meningoencephalitis.The American journal of tropical medicine and hygiene · 2013Article
- Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Scrub typhus and cerebrovascular injury: a phenomenon of delayed treatment?The American journal of tropical medicine and hygiene · 2013Article
- Microdialysis study of cefotaxime cerebral distribution in patients with acute brain injury.Antimicrobial agents and chemotherapy · 2013Article
- Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications.Journal of pharmacokinetics and pharmacodynamics · 2013Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial therapy for brain infections is notoriously difficult because of the limited extent of knowledge about drug penetration into the brain. Therefore, we determined the penetration of rifampin into various compartments of the human brain, including the cerebral extracellular space (CES). Patients undergoing craniotomy for resection of primary brain tumors were given a standard dose of 600 mg of rifampin intravenously before the operation. A microdialysis probe (10 by 0.5 mm) was inserted into the cortex distantly from the resection and was perfused with two different rifampin solutions. Rifampin concentrations in the CES were calculated by the no-net-flux method. Intraoperatively, samples were taken from brain tumor tissue, perifocal tissue, and normal brain tissue in the case of pole resections. Rifampin concentrations in the various samples were determined by using a bioassay with Sarcinea lutea. In the various compartments, rifampin concentrations were highest within tumors (1.37 +/- 1.34 microg/ml; n = 8), followed by the perifocal region (0.62 +/- 0.67 microg/ml; n = 8), the CES (0.32 +/- 0.11 microg/ml; n = 6), and normal brain tissue (0.29 +/- 0.15 microg/ml; n = 7). Rifampin concentrations in brain tumors do not adequately reflect concentrations in normal brain tissue or in the CES. Rifampin concentrations in the CES, as determined by microdialysis, are the most reproducible, and the least scattered, of the values for all compartments evaluated. Rifampin concentrations in all compartments exceed the MIC for staphylococci and streptococci. However, CES concentrations may be below the MICs for some mycobacterial strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.