ArticleAntimicrobial agents and chemotherapy1998
In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles.
Article in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Optimization of diformylfuran production from 5-hydroxymethylfurfuralRSC advances · 2024Article
- Selective Electrocatalytic Oxidation of Biomass-Derived 5-Hydroxymethylfurfural to 2,5-Diformylfuran: from Mechanistic Investigations to Catalyst Recovery.ChemSusChem · 2020Article
- Fenbendazole ControlsAntimicrobial agents and chemotherapy · 2020Article
- Article
- Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens.Antimicrobial agents and chemotherapy · 2015Article
- Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping.Organic letters · 2014Article
- Novel 4-substituted phenyl-2,2'-bichalcophenes and aza-analogs as antibacterial agents: a structural activity relationship.Drug design, development and therapy · 2013Article
- Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.Bioorganic & medicinal chemistry · 2011Article
- Chitin or chitin-like glycans as targets for late-term cancer chemoprevention.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.Journal of medicinal chemistry · 2010Article
- 4-Ammonio-benzamidinium dichloride.Acta crystallographica. Section E, Structure reports online · 2008Article
- Activities of dicationic compounds against Trichomonas vaginalis.Antimicrobial agents and chemotherapy · 2004Article
- The synthesis of dicationic extended bis-benzimidazoles.Molecules (Basel, Switzerland) · 2004Article
- Antifungal activity of nonantifungal drugs.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2003Review
- Decoration of dihydropyrimidine and dihydropyridine scaffolds with sugars via Biginelli and Hantzsch multicomponent reactions: an efficient entry to a collection of artificial nucleosides.Molecular diversity · 2003Article
- Immunoassays for pentamidine and related compounds: development of a facile inhibitory ELISA suitable for clinical use.Journal of clinical laboratory analysis · 2000Article
- Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.Antimicrobial agents and chemotherapy · 1999Article
- Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target.Genetics · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Aromatic dicationic compounds possess antimicrobial activity against a wide range of eucaryotic pathogens, and in the present study an examination of the structures-functions of a series of compounds against fungi was performed. Sixty-seven dicationic molecules were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. The MICs of a large number of compounds were comparable to those of the standard antifungal drugs amphotericin B and fluconazole. Unlike fluconazole, potent inhibitory compounds in this series were found to have excellent fungicidal activities. The MIC of one of the most potent compounds against C. albicans was 0.39 microg/ml, and it was the most potent compound against C. neoformans (MIC, </=0.09 microg/ml). Selected compounds were also found to be active against Aspergillus fumigatus, Fusarium solani, Candida species other than C. albicans, and fluconazole-resistant strains of C. albicans and C. neoformans. Since some of these compounds have been safely given to animals, these classes of molecules have the potential to be developed as antifungal agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.