ArticleAntimicrobial agents and chemotherapy1998
Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.
Article in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Synergistic Antifungal Activity of Pentamidine and Auranofin Against Multidrug-Resistant Candida auris.Mycopathologia · 2025Article
- Synthesis and anti-inflammatory activity of benzimidazole derivatives; an in vitro, in vivo and in silico approach.Heliyon · 2024Article
- Identification of four compounds from the Pharmakon library with antifungal activity against Candida auris and species of Cryptococcus.Medical mycology · 2022Article
- Revisit to the synthesis of 1,2,3,4-tetrasubstituted pyrrole derivatives in lactic acid media as a green solvent and catalyst.Molecular diversity · 2021Article
- Highly efficient and tunable visible-light-catalytic synthesis of 2,5-diformylfuran using HBr and molecular oxygen.RSC advances · 2021Article
- One-pot synthesis of dihydro-8H acenaphtho[1',2':4,5]pyrrolo[1,2-a]imidazole-diol derivatives.Molecular diversity · 2021Article
- Bioengineering advancements, innovations and challenges on green synthesis of 2, 5-furan dicarboxylic acid.Bioengineered · 2020Review
- Efficient and environmentally sustainable domino protocol for the synthesis of diversified spiroheterocycles with privileged heterocyclic substructures using bio-organic catalyst in aqueous medium.Molecular diversity · 2020Article
- Fenbendazole ControlsAntimicrobial agents and chemotherapy · 2020Article
- Co-Immobilization of Tri-Enzymes for the Conversion of Hydroxymethylfurfural to 2,5-Diformylfuran.Molecules (Basel, Switzerland) · 2019Article
- Transition metal-free one-pot synthesis of substituted pyrroles by employing aza-Wittig reaction.RSC advances · 2019Article
- Small molecule binders recognize DNA microstructural variations via an induced fit mechanism.Physical chemistry chemical physics : PCCP · 2019Article
- Article
- Selective Oxidation of Biomass-Derived Alcohols and Aromatic and Aliphatic Alcohols to Aldehydes with OACS omega · 2018Article
- Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds.Bioorganic & medicinal chemistry · 2015Article
- Synthesis and antifungal activity of benzamidine derivatives carrying 1,2,3-triazole moieties.Molecules (Basel, Switzerland) · 2014Article
- Bis[2-(4-amino-phen-yl)-4,5-dihydro-1H-imidazol-3-ium] dichloride monohydrate.Acta crystallographica. Section E, Structure reports online · 2011Article
- Novel diamidines with activity against Babesia divergens in vitro and Babesia microti in vivo.Antimicrobial agents and chemotherapy · 2011Article
- Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.Bioorganic & medicinal chemistry · 2011Article
- 4-Ammonio-benzamidinium dichloride.Acta crystallographica. Section E, Structure reports online · 2008Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Twenty analogues of pentamidine, 7 primary metabolites of pentamidine, and 30 dicationic substituted bis-benzimidazoles were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. A majority of the compounds had MICs at which 80% of the strains were inhibited (MIC80s) comparable to those of amphotericin B and fluconazole. Unlike fluconazole, many of these compounds were found to have potent fungicidal activity. The most potent compound against C. albicans had an MIC80 of </=0.09 microg/ml, and the most potent compound against C. neoformans had an MIC80 of 0.19 microg/ml. Selected compounds were also found to be active against Aspergillus fumigatus, Fusarium solani, Candida species other than C. albicans, and fluconazole-resistant strains of C. albicans and C. neoformans. It is clear from the data presented here that further studies on the structure-activity relationships, mechanisms of action and toxicities, and in vivo efficacies of these compounds are warranted to determine their clinical potential.
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