ArticleGenetics1998
Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Evaluation of the vestibulo-ocular reflex in head-tilt mutant mice.Biochemistry and biophysics reports · 2025Article
- Effect of Pycnogenol® on Noise-Induced Hearing Loss in Rats.The journal of international advanced otology · 2025Article
- Increased Homer Activity and NMJ Localization in the Vestibular LesionInternational journal of molecular sciences · 2024Article
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Behavioral and neural responses to high-strength magnetic fields are reduced in otolith mutant mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Genetic studies of human-chimpanzee divergence using stem cell fusions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neural Interruption by Unilateral Labyrinthectomy Biases the Directional Preference of Otolith-Related Vestibular Neurons.Brain sciences · 2021Article
- The Growing Evidence for the Importance of the Otoliths in Spatial Memory.Frontiers in neural circuits · 2019Review
- Mouse Magnetic-field Nystagmus in Strong Static Magnetic Fields Is Dependent on the Presence of Nox3.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2018Article
- Vestibular dysfunction, altered macular structure and trait localization in A/J inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Genetics of peripheral vestibular dysfunction: lessons from mutant mouse strains.Journal of the American Academy of Audiology · 2014Review
- Ontogeny of mouse vestibulo-ocular reflex following genetic or environmental alteration of gravity sensing.PloS one · 2012Article
- A preformed scleral search coil for measuring mouse eye movements.Journal of neuroscience methods · 2010Article
- Resting discharge patterns of macular primary afferents in otoconia-deficient mice.Journal of the Association for Research in Otolaryngology : JARO · 2008Article
- A comparison of vestibular and auditory phenotypes in inbred mouse strains.Brain research · 2006Article
- A quantitative survey of gravity receptor function in mutant mouse strains.Journal of the Association for Research in Otolaryngology : JARO · 2005Article
- Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.Developmental biology · 2004Article
- Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase.Genes & development · 2004Article
- Overlapping deletions spanning the proximal two-thirds of the mouse t complex.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection?Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Head tilt (het) is a recessive mutation in mice causing vestibular dysfunction. Homozygotes display abnormal responses to position change and linear acceleration and cannot swim. However, they are not deaf. het was mapped to the proximal region of mouse chromosome 17, near the T locus. Here we report anatomical characterization of het mutants and high resolution mapping using a set of chromosome deletions. The defect in het mutants is limited to the utricle and saccule of the inner ear, which completely lack otoliths. The unique specificity of the het mutation provides an opportunity to better understand the development of the vestibular system. Complementation analyses with a collection of embryonic stem (ES)- and germ cell-induced deletions localized het to an interval near the centromere of chromosome 17 that was indivisible by recombination mapping. This approach demonstrates the utility of chromosome deletions as reagents for mapping and characterizing mutations, particularly in situations where recombinational mapping is inadequate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.