ArticleGenetics1998
Quantitative genetic analysis of copia retrotransposon activity in inbred Drosophila melanogaster lines.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Genetic variation in P-element dysgenic sterility is associated with double-strand break repair and alternative splicing of TE transcripts.PLoS genetics · 2022Article
- The Transposition Rate Has Little Influence on the Plateauing Level of the P-element.Molecular biology and evolution · 2022Article
- Tempo and Mode of Transposable Element Activity in Drosophila.PLoS genetics · 2015Article
- Co-evolution between transposable elements and their hosts: a major factor in genome size evolution?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Review
- Article
- Inferring the strength of selection in Drosophila under complex demographic models.Molecular biology and evolution · 2009Article
- Direct determination of the effects of genotype and extreme temperature on the transposition of roo in long-term mutation accumulation lines of Drosophila melanogaster.Molecular genetics and genomics : MGG · 2007Article
- The dynamics of the roo transposable element in mutation-accumulation lines and segregating populations of Drosophila melanogaster.Genetics · 2007Article
- The fate of transposable elements in asexual populations.Genetics · 2006Article
- Characterization of active R2 retrotransposition in the rDNA locus of Drosophila simulans.Genetics · 2005Article
- Estimates of the genomic mutation rate for detrimental alleles in Drosophila melanogaster.Genetics · 2004Article
- Article
- Female age and sperm competition: last-male precedence declines as female age increases.Proceedings. Biological sciences · 2003Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The rates of transcription and transposition of retrotransposons vary between lines of Drosophila melanogaster. We have studied the genetics of differences in copia retrotransposon activity by quantitative trait loci (QTL) mapping. Ninety-eight recombinant inbred lines were constructed from two parental lines exhibiting a 10-fold difference in copia transcript level and a 100-fold difference in transposition rate. The lines were scored for 126 molecular markers, copia transcript level, and rate of copia transposition. Transcript level correlated with copia copy number, and the difference in copia copy number between parental lines accounted for 45.1% of copia transcript-level difference. Most of the remaining difference was accounted for by two transcript-level QTL mapping to cytological positions 27B-30D and 50F-57C on the second chromosome, which accounted for 11.5 and 30.4%, respectively. copia transposition rate was controlled by interacting QTL mapping to the region 27B-48D on the second and 61A-65A and 97D-100A on the third chromosome. The genes controlling copia transcript level are thus not necessarily those involved in controlling copia transposition rate. Segregation of modifying genes, rather than mutations, might explain the variability in copia retrotransposon activity between lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.