ArticleGenetics1998
Y-Linked male sterile mutations induced by P element in Drosophila melanogaster.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- The Role of Y Chromosome Genes in Male Fertility inGenetics · 2020Article
- Dissecting Fertility Functions ofGenetics · 2020Article
- miRNA-1-3p is an early embryonic male sex-determining factor in the Oriental fruit fly Bactrocera dorsalis.Nature communications · 2020Article
- Combover interacts with the axonemal component Rsp3 and is required forDevelopment (Cambridge, England) · 2019Article
- Site-specific transgenesis of the Drosophila melanogaster Y-chromosome using CRISPR/Cas9.Insect molecular biology · 2019Article
- Article
- Drosophila spermiogenesis: Big things come from little packages.Spermatogenesis · 2012Article
- A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes.PLoS genetics · 2010Article
- Article
- Genetics of P-element transposition into Drosophila melanogaster centric heterochromatin.Genetics · 2003Article
- Efficient recovery of centric heterochromatin P-element insertions in Drosophila melanogaster.Genetics · 2002Article
- Y chromosomal fertility factors kl-2 and kl-3 of Drosophila melanogaster encode dynein heavy chain polypeptides.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Article
- A trans-activator on the Drosophila Y chromosome regulates gene expression in the male germ line.Genetica · 2000Article
- Common mechanisms of Y chromosome evolution.Genetica · 2000Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Y chromosome in Drosophila melanogaster is composed of highly repetitive sequences and is essential only in the male germ line. We employed P-element insertional mutagenesis to induce male sterile mutations in the Y chromosome. By using a combination of two modifiers of position effect variegation, adding an extra Y chromosome and increasing temperature, we isolated 61 P(ry+) elements in the Y chromosome. Six of these Y-linked insertions (approximately 10%) induced male sterile mutations that are mapped to two genes on the long and one on the short arms of the Y chromosome. These mutations are revertible to the wild type in a cell-autonomous and germ-line-dependent manner, consistent with previously defined Y-linked gene functions. Phenotypes associated with these P-induced mutations are similar to those resulting from deletions of the Y chromosome regions corresponding to the male fertility genes. Three alleles of the kl-3 gene on the Y long arm result in loss of the axonemal outer dynein arms in the spermatid tail, while three ks-2 alleles on the Y short arm induce defects at early postmeiotic stages. The recovery of the ms(Y) mutations induced by single P-element insertions will facilitate our effort to understand the structural and functional properties of the Y chromosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.