ArticleGenetics1998
Expression and properties of wild-type and mutant forms of the Drosophila sex comb on midleg (SCM) repressor protein.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 78 citations in OpenAlex.
- Polycomb group genes are required for neuronal pruning in Drosophila.BMC biology · 2023Article
- Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila.Genes & development · 2015Article
- Polycomb group genes are required to maintain a binary fate choice in the Drosophila eye.Neural development · 2015Article
- Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes.eLife · 2014Article
- Solution NMR structure of the DNA-binding domain from Scml2 (sex comb on midleg-like 2).The Journal of biological chemistry · 2014Article
- Small ubiquitin-like modifier (SUMO) conjugation impedes transcriptional silencing by the polycomb group repressor Sex Comb on Midleg.The Journal of biological chemistry · 2011Article
- H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.PLoS genetics · 2011Article
- Identification of non-peptide malignant brain tumor (MBT) repeat antagonists by virtual screening of commercially available compounds.Journal of medicinal chemistry · 2010Article
- Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a Drosophila Hox gene.Molecular and cellular biology · 2010Article
- MBT domain proteins in development and disease.Seminars in cell & developmental biology · 2010Review
- Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt.The EMBO journal · 2009Article
- Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2.Nucleic acids research · 2009Article
- Article
- Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.Molecular cell · 2007Article
- Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg.EMBO reports · 2007Article
- Article
- Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex.Genes & development · 2004Article
- Cross-regulation among the polycomb group genes in Drosophila melanogaster.Molecular and cellular biology · 2004Article
- Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression.Genetics · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Sex comb on midleg (Scm) gene encodes a transcriptional repressor of the Polycomb group (PcG). Here we show that SCM protein is nuclear and that its expression is widespread during fly development. SCM protein contains a C-terminal domain, termed the SPM domain, which mediates protein-protein interactions. The biochemical function of another domain consisting of two 100-amino-acid-long repeats, termed "mbt" repeats, is unknown. We have determined the molecular lesions of nine Scm mutant alleles, which identify functional requirements for specific domains. The Scm alleles were tested for genetic interactions with mutations in other PcG genes. Intriguingly, three hypomorphic Scm mutations, which map within an mbt repeat, interact with PcG mutations more strongly than do Scm null alleles. The strongest interactions produce partial synthetic lethality that affects doubly heterozygous females more severely than males. We show that mbt repeat alleles produce stable SCM proteins that associate with normal sites in polytene chromosomes. We also analyzed progeny from Scm mutant germline clones to compare the effects of an mbt repeat mutation during embryonic vs. pupal development. We suggest that the mbt repeat alleles produce altered SCM proteins that incorporate into and impair function of PcG protein complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.