ArticleThe EMBO journal1998
Cdc18 transcription and proteolysis couple S phase to passage through mitosis.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Nrm1 is a bistable switch connecting cell cycle progression to transcriptional control.EMBO reports · 2025Article
- The Archaeal Cell Cycle.Annual review of cell and developmental biology · 2024Review
- Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication.Molecular cell · 2021Article
- Article
- Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeastThe Journal of biological chemistry · 2017Article
- Regulating DNA replication in eukarya.Cold Spring Harbor perspectives in biology · 2013Review
- Ongoing DNA synthesis in the rat cerebral cortex is regulated by a proteolytic pathway independent of the proteasome and calpains.Investigational new drugs · 2010Article
- The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress.PloS one · 2009Article
- Plant geminivirus rep protein induces rereplication in fission yeast.Journal of virology · 2009Article
- Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.Nucleic acids research · 2007Article
- The cell cycle-regulated genes of Schizosaccharomyces pombe.PLoS biology · 2005Article
- The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation.The Journal of cell biology · 2004Article
- Eukaryotic MCM proteins: beyond replication initiation.Microbiology and molecular biology reviews : MMBR · 2004Review
- Phosphorylation of the PCNA binding domain of the large subunit of replication factor C on Thr506 by cyclin-dependent kinases regulates binding to PCNA.Nucleic acids research · 2003Article
- Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.The EMBO journal · 2003Article
- The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.The EMBO journal · 2002Article
- Analysis of Cdc6 function in the assembly of mammalian prereplication complexes.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Essential role of MCM proteins in premeiotic DNA replication.Molecular biology of the cell · 2002Article
- Replication licensing--defining the proliferative state?Trends in cell biology · 2002Review
- Redundant control of rereplication in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In fission yeast, cdc18p plays a critical role in bringing about the onset of S phase. We show that cdc18p expression is subject to a complex sequence of cell cycle controls which ensure that cdc18p levels rise dramatically as cells exit mitosis, before the appearance of CDK activity in G1. We find that transcription of cdc18, together with the transcription of other cdc10p/res1p targets, is first initiated as cells enter mitosis and continues even in cells arrested in mitosis with highly condensed chromatin. However, cdc18p cannot accumulate during mitosis because it is targeted for proteolysis by mitotic cdc2p-protein kinase-mediated phosphorylation. On exit from mitosis, the cdc2p mitotic kinase activity falls, stabilizing cdc18p, which then rapidly accumulates. This combination of mitotic transcription and CDK-mediated proteolysis ensures that progression through mitosis simultaneously prepares cells for DNA replication. During S phase, cdc18 transcription is then switched off, preventing the re-initiation of DNA synthesis until the completion of the next round of mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.