ArticleDigestive diseases and sciences1998
Quantitative and ultrastructural analysis of rectal mucosal mast cells in acute infectious diarrhea.
Article in Digestive diseases and sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- ProbioticNutrients · 2019Trial
- The Complex Link and Disease Between the Gut Microbiome and the Immune System in Infants.Frontiers in cellular and infection microbiology · 2022Review
- Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea.World journal of gastroenterology · 2011Article
- Physiological and pathophysiological functions of intestinal mast cells.Seminars in immunopathology · 2009Review
- Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats.Journal of natural medicines · 2008Article
- Development of colorectal sensitization is associated with increased eosinophils and mast cells in dextran sulfate sodium-treated rats.Digestive diseases and sciences · 2004Article
- Article
- Persistence of mucosal mast cells and eosinophils in Shigella-infected children.Infection and immunity · 2003Article
- Manipulation of cell surface macromolecules by flaviviruses.Advances in virus research · 2003Review
- Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139.Clinical and diagnostic laboratory immunology · 2002Article
- Release of vasoactive cytokines by antibody-enhanced dengue virus infection of a human mast cell/basophil line.Journal of virology · 2000Article
- Innate immune responses in children and adults with Shigellosis.Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of mast cells, potential mediators of mucosal immunity and inflammation, was studied morphologically in the rectal mucosa in two acute diarrheal diseases, cholera and shigellosis. Quantitation of mucosal mast cells showed that they were significantly higher in the deeper lamina propria where blood vessels and nerves were more abundant. There was no difference in mast cell counts or degranulation in the mucosa in both groups of patients and controls. Intraepithelial mast cells were decreased in the patients. The prevalence of lipid bodies was significantly higher in mast cells from patients with cholera and shigellosis (P < 0.01). These findings suggest that mast cell populations are more dense around blood vessels and nerves and that inflammatory mediators derived from arachidonic acid metabolites, as indicated by the lipid bodies, are the response of mast cells to the alterations in diarrhea, despite differences in the etiology of diarrhea.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.