ArticleProceedings of the National Academy of Sciences of the United States of America1998
Evidence for posttranscriptional activation of gamma-glutamylcysteine synthetase during plant stress responses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed.
- Phytochelatins: Sulfur-Containing Metal(loid)-Chelating Ligands in Plants.International journal of molecular sciences · 2023Review
- Transcript profiling of glutathione metabolizing genes reveals abiotic stress and glutathione-specific alteration inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Low-molecular-weight ligands in plants: role in metal homeostasis and hyperaccumulation.Photosynthesis research · 2021Review
- In Vivo Imaging with Genetically Encoded Redox Biosensors.International journal of molecular sciences · 2020Review
- MicroRNA-mRNA expression profiles and their potential role in cadmium stress response in Brassica napus.BMC plant biology · 2019Article
- The PhotorespiratoryFrontiers in plant science · 2018Article
- Influence of sulfur and cadmium on antioxidants, phytochelatins and growth in Indian mustard.AoB PLANTS · 2015Article
- The significance of cysteine synthesis for acclimation to high light conditions.Frontiers in plant science · 2014Article
- Antioxidant Defenses in Plants with Attention to Prunus and Citrus spp.Antioxidants (Basel, Switzerland) · 2013Review
- Thiol synthetases of legumes: immunogold localization and differential gene regulation by phytohormones.Journal of experimental botany · 2012Article
- Glutathione deficiency of the Arabidopsis mutant pad2-1 affects oxidative stress-related events, defense gene expression, and the hypersensitive response.Plant physiology · 2011Article
- Glutathione as a signaling molecule: another challenge to pathogens.Plant signaling & behavior · 2011Review
- Plant glutathione biosynthesis: diversity in biochemical regulation and reaction products.Frontiers in plant science · 2011Article
- Glutathione.The arabidopsis book · 2011Article
- Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Function of antioxidant enzymes and metabolites during maturation of pea fruits.Journal of experimental botany · 2010Article
- Molecular cloning and characterization of a gamma-glutamylcysteine synthetase gene from Chorispora bungeana.Protoplasma · 2009Article
- Ascorbate and homoglutathione metabolism in common bean nodules under stress conditions and during natural senescence.Plant physiology · 2008Article
- Thiol-based regulation of redox-active glutamate-cysteine ligase from Arabidopsis thaliana.The Plant cell · 2007Article
- The shoot-specific expression of gamma-glutamylcysteine synthetase directs the long-distance transport of thiol-peptides to roots conferring tolerance to mercury and arsenic.Plant physiology · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione (GSH) is a key component of plant antioxidant defenses. We have sought to determine how the rate-limiting step in GSH biosynthesis, catalyzed by gamma-glutamylcysteine synthase (gammaECS) is regulated in Arabidopsis. Functional complementation of a yeast mutant deficient in this enzyme with an Arabidopsis expression library yielded two cDNAs with sequence identical to the previously described AtgammaECS. Nevertheless, the cellular concentration of GSH in these transformants was only 10% of wild-type concentrations and this was not a result of Cys availability. To explore the possibility that Arabidopsis gammaECS requires additional factors for full catalytic activity, we analyzed the GSH levels and the enzyme activities and transcript levels of both enzymes of the GSH biosynthetic pathway in Arabidopsis suspension cultures subjected to a variety of stresses that raise GSH levels. Our results demonstrate rapid posttranscriptional activation of Arabidopsis gammaECS. The implications of these findings for the mechanisms by which GSH concentrations are regulated during plant-stress responses are discussed.
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