ArticleProceedings of the National Academy of Sciences of the United States of America1998
LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation.The Journal of clinical investigation · 2024Article
- HLA-B*27 Heavy Chain Homo-Oligomers Promote the Cytotoxicity of NK Cells via Activation of PI3K/AKT Signaling.Medicina (Kaunas, Lithuania) · 2022Article
- Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling.Frontiers in immunology · 2022Article
- Identification and Characterization of the Amphioxus Lck and Its Associated Tyrosine Phosphorylation-Dependent Inhibitory LRR Receptor.Frontiers in immunology · 2021Article
- CD8αα homodimers function as a coreceptor for KIR3DL1.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Impact of Immunodeficiency on NK Cell Maturation and Function.Current allergy and asthma reports · 2019Review
- Phosphoinositide-3-Kinase Signaling in Human Natural Killer Cells: New Insights from Primary Immunodeficiency.Frontiers in immunology · 2018Review
- Functional NK cell repertoires are maintained through IL-2Rα and Fas ligand.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Multiplex and genome-wide analyses reveal distinctive properties of KIR+ and CD56+ T cells in human blood.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells.Cell death and differentiation · 2013Article
- Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling.Blood · 2013Article
- Role of inositol phospholipid signaling in natural killer cell biology.Frontiers in immunology · 2013Article
- Inositol phospholipid signaling and the biology of natural killer cells.Journal of innate immunity · 2011Review
- Inhibitor and activator: dual functions for SHIP in immunity and cancer.Annals of the New York Academy of Sciences · 2011Review
- Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation.Frontiers in bioscience (Landmark edition) · 2009Review
- Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells.The Journal of experimental medicine · 2006Article
- Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells.The Journal of experimental medicine · 2003Article
- Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- ITAMs versus ITIMs: striking a balance during cell regulation.The Journal of clinical investigation · 2002Review
- DAP12 and KAP10 (DAP10)-novel transmembrane adapter proteins of the CD3zeta family.Immunologic research · 2000Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
HLA-specific killer cell inhibitory receptors (KIR) are thought to impede natural killer (NK) and T cell activation programs through recruitment of the SH2 domain-containing tyrosine phosphatases, SHP-1 and SHP-2, to their cytoplasmic tails (CYT). To identify other SH2 domain-containing proteins that bind KIR CYT, we used the recently described yeast two-bait interaction trap and a modified version of this system, both of which permit tyrosine phosphorylation of bait proteins. Using these systems, we show that KIR CYT, once phosphorylated by the src-family tyrosine kinase LCK, additionally bind the p85alpha regulatory subunit of phosphatidylinositol (PI) 3-kinase. Furthermore, we show that in an NK cell line, NK3.3, cross-linking of KIR results in recruitment of p85alpha to KIR and activation of PI 3-kinase lipid kinase activity. One consequence of KIR coupling to PI 3-kinase is downstream activation of the antiapoptotic protein kinase AKT. Therefore, in addition to providing negative signals, KIR may also contribute positive signals for NK and T cell growth and/or survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.