ArticleProceedings of the National Academy of Sciences of the United States of America1998
Amitochondriate amoebae and the evolution of DNA-dependent RNA polymerase II.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 68 citations in OpenAlex.
- RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.Chemical reviews · 2013Review
- Article
- Eukaryote-to-eukaryote gene transfer gives rise to genome mosaicism in euglenids.BMC evolutionary biology · 2011Article
- Multivesicular bodies in the enigmatic amoeboflagellate Breviata anathema and the evolution of ESCRT 0.Journal of cell science · 2011Article
- The non-canonical CTD of RNAP-II is essential for productive RNA synthesis in Trypanosoma brucei.PloS one · 2009Article
- Cyanobacterial contribution to the genomes of the plastid-lacking protists.BMC evolutionary biology · 2009Article
- Origins of a cyanobacterial 6-phosphogluconate dehydrogenase in plastid-lacking eukaryotes.BMC evolutionary biology · 2008Article
- A multistep process gave rise to RNA polymerase IV of land plants.Journal of molecular evolution · 2007Article
- Loss of the flagellum happened only once in the fungal lineage: phylogenetic structure of kingdom Fungi inferred from RNA polymerase II subunit genes.BMC evolutionary biology · 2006Article
- Glucose signaling in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2006Review
- A new scenario of plastid evolution: plastid primary endosymbiosis before the divergence of the "Plantae," emended.Journal of plant research · 2005Review
- Inter-species horizontal transfer resulting in core-genome and niche-adaptive variation within Helicobacter pylori.BMC genomics · 2005Article
- Evolution of eukaryotic transcription: insights from the genome of Giardia lamblia.Genome research · 2004Article
- Cyanobacterial genes transmitted to the nucleus before divergence of red algae in the Chromista.Journal of molecular evolution · 2004Article
- Evolution of the RNA polymerase II C-terminal domain.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The analysis of 100 genes supports the grouping of three highly divergent amoebae: Dictyostelium, Entamoeba, and Mastigamoeba.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Microsporidia are related to Fungi: evidence from the largest subunit of RNA polymerase II and other proteins.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unlike parasitic protist groups that are defined by the absence of mitochondria, the Pelobiontida is composed mostly of free-living species. Because of the presence of ultrastructural and cellular features that set them apart from all other eukaryotic organisms, it has been suggested that pelobionts are primitively amitochondriate and may represent the earliest-evolved lineage of extant protists. Analyses of rRNA genes, however, have suggested that the group arose well after the diversification of the earliest-evolved protists. Here we report the sequence of the gene encoding the largest subunit of DNA-dependent RNA polymerase II (RPB1) from the pelobiont Mastigamoeba invertens. Sequences within RPB1 encompass several of the conserved catalytic domains that are common to eubacterial, archaeal, and eukaryotic nuclear-encoded RNA polymerases. In RNA polymerase II, these domains catalyze the transcription of all nuclear pre-mRNAs, as well as the majority of small nuclear RNAs. In contrast with rDNA-based trees, phylogenetic analyses of RPB1 sequences indicate that Mastigamoeba represents an early branch of eukaryotic evolution. Unlike sequences from parasitic amitochondriate protists that were included in our study, there is no indication that Mastigamoeba RPB1 is attracted to the base of the eukaryotic tree artifactually. In addition, the presence of introns and a heptapeptide C-terminal repeat in the Mastigamoeba RPB1 sequence, features that are typically associated with more recently derived eukaryotic groups, raise provocative questions regarding models of protist evolution that depend almost exclusively on rDNA sequence analyses.
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