ArticleProceedings of the National Academy of Sciences of the United States of America1998
Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 122 citations in OpenAlex.
- Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels.Frontiers in physiology · 2024Review
- Autophagy in Plants: Both a Puppet and a Puppet Master of Sugars.Frontiers in plant science · 2019Review
- KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Dose-Duration Reciprocity for G protein activation: Modulation of kinase to substrate ratio alters cell signaling.PloS one · 2017Article
- Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.The Biochemical journal · 2016Article
- Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool.PLoS biology · 2015Article
- Short-term desensitization of muscarinic K+ current in the heart.Biophysical journal · 2013Article
- Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- GIRK channel modulation by assembly with allosterically regulated RGS proteins.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Neuropeptide transmission in brain circuits.Neuron · 2012Review
- Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling.The Journal of biological chemistry · 2010Article
- CCR5 ligands modulate CXCL12-induced chemotaxis, adhesion, and Akt phosphorylation of human cord blood CD34+ cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins.Trends in pharmacological sciences · 2008Review
- Coordinating speed and amplitude in G-protein signaling.Current biology : CB · 2008Review
- And the winner is ... RGS4!Circulation research · 2008Article
- Motor coordination deficits in mice lacking RGS9.Brain research · 2008Article
- Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.Molecular and cellular biology · 2006Article
- Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.The Journal of cell biology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The G-protein gated inward rectifier K+ channel (GIRK) is activated in vivo by the Gbeta gamma subunits liberated upon Gi-coupled receptor activation. We have recapitulated the acute desensitization of receptor-activated GIRK currents in heterologous systems and shown that it is a membrane-delimited process. Its kinetics depends on the guanine nucleotide species available and could be accounted for by the nucleotide exchange and hydrolysis cycle of G proteins. Indeed, acute desensitization is abolished by nonhydrolyzable GTP analogues. Whereas regulators of G-protein signaling (RGS) proteins by their GTPase-activating protein activities are regarded as negative regulators, a positive regulatory function of RGS4 is uncovered in our study; the opposing effects allow RGS4 to potentiate acute desensitization without compromising GIRK activation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.