ArticleProceedings of the National Academy of Sciences of the United States of America1998
A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- Article
- HPV is a cargo for the COPI sorting complex during virus entry.Science advances · 2023Article
- A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE).BMC bioinformatics · 2017Article
- 9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.eLife · 2017Article
- A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling.Cellular signalling · 2015Article
- Review
- The Golgi-localized Arabidopsis endomembrane protein12 contains both endoplasmic reticulum export and Golgi retention signals at its C terminus.The Plant cell · 2012Article
- COPI budding within the Golgi stack.Cold Spring Harbor perspectives in biology · 2011Review
- Review
- Hereditary spastic paraplegia and amyotrophy associated with a novel locus on chromosome 19.Neurogenetics · 2010Article
- Essential lysine residues within transmembrane helix 1 of diphtheria toxin facilitate COPI binding and catalytic domain entry.Molecular microbiology · 2010Article
- mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles.Molecular biology of the cell · 2009Article
- Mechanisms of cardiac potassium channel trafficking.The Journal of physiology · 2007Review
- Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins.Molecular and cellular biology · 2006Article
- COPI-mediated transport.The Journal of membrane biology · 2006Review
- Intracellular targeting signals contribute to localization of coronavirus spike proteins near the virus assembly site.Journal of virology · 2004Article
- The alpha- and beta'-COP WD40 domains mediate cargo-selective interactions with distinct di-lysine motifs.Molecular biology of the cell · 2004Article
- Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals.Molecular and cellular biology · 2004Article
- Functional reconstitution of COPI coat assembly and disassembly using chemically defined components.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Genome-wide detection of tissue-specific alternative splicing in the human transcriptome.Nucleic acids research · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coatomer, the major component of the coat of COPI transport vesicles, binds both to the dilysine motif of resident membrane proteins of the endoplasmic reticulum and to the cytoplasmic domain of p23, a major type I membrane protein of COPI vesicles. Using a photocrosslinking approach, we find that under native conditions a peptide analogous to the cytoplasmic domain of p23 interacts with coatomer exclusively through its gamma subunit and shares its binding site with a KKXX retrieval motif. However, upon dissociation of coatomer, interaction with various subunits, including an alpha-, beta'-, epsilon-COP subcomplex, of the photoreactive peptide is observed. We suggest that, under physiological conditions, interaction of coatomer with both endoplasmic reticulum retrieval motifs and the cytoplasmic domain of p23 is mediated by gamma-COP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.