ArticleProceedings of the National Academy of Sciences of the United States of America1997
Photorepair mutants of Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Plant tolerance mechanisms to DNA-damaging UV stress.Journal of experimental botany · 2025Review
- The photoreactivation of 6 - 4 photoproducts in chloroplast and nuclear DNA depends on the amount of the Arabidopsis UV repair defective 3 protein.BMC plant biology · 2024Article
- Global repair is the primary nucleotide excision repair subpathway for the removal of pyrimidine-pyrimidone (6-4) damage from the Arabidopsis genome.Scientific reports · 2024Article
- Plant responses to UV-B radiation: signaling, acclimation and stress tolerance.Stress biology · 2022Review
- Positive selection and heat-response transcriptomes reveal adaptive features of the Brassicaceae desert model, Anastatica hierochuntica.The New phytologist · 2022Article
- Structural Aspects of DNA Repair and Recombination in Crop Improvement.Frontiers in genetics · 2020Review
- Redox Balance-DDR-miRNA Triangle: Relevance in Genome Stability and Stress Responses in Plants.Frontiers in plant science · 2019Review
- UVR2 ensures transgenerational genome stability under simulated natural UV-B in Arabidopsis thaliana.Nature communications · 2016Article
- Integration and scaling of UV-B radiation effects on plants: from DNA to leaf.Ecology and evolution · 2015Article
- The regulation of UV-B responses by the circadian clock.Plant signaling & behavior · 2015Article
- DNA damage and repair in plants - from models to crops.Frontiers in plant science · 2015Review
- DNA damage and repair in plants under ultraviolet and ionizing radiations.TheScientificWorldJournal · 2015Review
- UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation.Journal of experimental botany · 2014Article
- The UV-B photoreceptor UVR8: from structure to physiology.The Plant cell · 2014Review
- Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants.The Journal of biological chemistry · 2012Article
- Research on plants for the understanding of diseases of nuclear and mitochondrial origin.Journal of biomedicine & biotechnology · 2012Review
- Genotoxic stress and DNA repair in plants: emerging functions and tools for improving crop productivity.Plant cell reports · 2011Review
- Atypical E2F activity coordinates PHR1 photolyase gene transcription with endoreduplication onset.The EMBO journal · 2011Article
- Arabidopsis cockayne syndrome A-like proteins 1A and 1B form a complex with CULLIN4 and damage DNA binding protein 1A and regulate the response to UV irradiation.The Plant cell · 2010Article
- Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance.Plant molecular biology · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
UV radiation induces two major DNA damage products, the cyclobutane pyrimidine dimer (CPD) and, at a lower frequency, the pyrimidine (6-4) pyrimidinone dimer (6-4 product). Although Escherichia coli and Saccharomyes cerevisiae produce a CPD-specific photolyase that eliminates only this class of dimer, Arabidopsis thaliana, Drosphila melanogaster, Crotalus atrox, and Xenopus laevis have recently been shown to photoreactivate both CPDs and 6-4 products. We describe the isolation and characterization of two new classes of mutants of Arabidopsis, termed uvr2 and uvr3, that are defective in the photoreactivation of CPDs and 6-4 products, respectively. We demonstrate that the CPD photolyase mutation is genetically linked to a DNA sequence encoding a type II (metazoan) CPD photolyase. In addition, we are able to generate plants in which only CPDs or 6-4 products are photoreactivated in the nuclear genome by exposing these mutants to UV light and then allowing them to repair one or the other class of dimers. This provides us with a unique opportunity to study the biological consequences of each of these two major UV-induced photoproducts in an intact living system.
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