ArticleInfection and immunity1998
Effects of orally administered epidermal growth factor on enteropathogenic Escherichia coli infection in rabbits.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants.Scientific reports · 2021Trial
- Recombinant porcine epidermal growth factor-secreting Lactococcus lactis promotes the growth performance of early-weaned piglets.BMC veterinary research · 2014Trial
- Maternal milk contains antimicrobial factors that protect young rabbits from enteropathogenic Escherichia coli infection.Clinical and vaccine immunology : CVI · 2007Trial
- Intravitreal panitumumab and retinal pigment epithelium proliferation in laser-induced retinal degeneration in rabbits.Frontiers in ophthalmology · 2025Article
- Growth performance and gastrointestinal responses of broiler chickens fed corn-soybean meal diet without or with exogenous epidermal growth factor upon challenge with Eimeria.Poultry science · 2017Article
- Angiogenic factors and inflammation in steroid-refractory acute graft-vs-host disease.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Epidermal Growth Factor and Intestinal Barrier Function.Mediators of inflammation · 2016Review
- Restoration of CpG Methylation in The Egf Promoter Region during Rat Liver Regeneration.Cell journal · 2015Article
- Strain-dependent induction of human enterocyte apoptosis by blastocystis disrupts epithelial barrier and ZO-1 organization in a caspase 3- and 9-dependent manner.BioMed research international · 2014Article
- Proton pump inhibitors are not the key for therapying non-steroidal anti-inflammatory drugs-induced small intestinal injury.Rheumatology international · 2013Article
- VIP and growth factors in the infected cornea.Investigative ophthalmology & visual science · 2011Article
- Effect of Lactobacillus acidophilus & epidermal growth factor on experimentally induced Clostridium difficile infection.The Indian journal of medical research · 2011Article
- ERBBs in the gastrointestinal tract: recent progress and new perspectives.Experimental cell research · 2009Review
- Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation.Infection and immunity · 2008Article
- Enteropathogenic Escherichia coli-induced epidermal growth factor receptor activation contributes to physiological alterations in intestinal epithelial cells.Infection and immunity · 2007Article
- Review
- Cloning and characterization of a bovine genomic fragment homologous to epidermal growth factor genes.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2004Article
- Role of CD8+ and CD4+ T lymphocytes in jejunal mucosal injury during murine giardiasis.Infection and immunity · 2004Article
- Article
- Jejunal brush border microvillous alterations in Giardia muris-infected mice: role of T lymphocytes and interleukin-6.Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increased intestinal absorption induced by epidermal growth factor (EGF) is associated with diffuse lengthening of brush border microvilli. The aim of this study was to examine the in vivo effects of oral administration of EGF during infection with enteropathogenic Escherichia coli. New Zealand White rabbits (4 weeks old) received orogastric EGF daily starting 3 days prior to infection with enteropathogenic E. coli RDEC-1 and were compared with sham-treated infected animals and uninfected controls. Weight gain, food intake, fecal E. coli, and stool consistency were assessed daily. On day 10, segments of jejunum, ileum, proximal, and distal colon were assessed for gram-negative bacterial colonization, disaccharidase activities, and epithelial ultrastructure. Effects of EGF on E. coli RDEC-1 proliferation were studied in vitro. E. coli RDEC-1 caused diarrhea and reduced weight gain. Seven days postinfection, the small and large intestines were colonized with numerous bacteria, brush border microvilli were disrupted, and maltase and sucrase activities were significantly reduced in the jejunum. Daily treatment with EGF prevented the occurrence of diarrhea and reduction of weight gain. These effects were associated with significant inhibition of E. coli colonization in the small and large intestine, improved jejunal maltase and sucrase activities and reduced microvillous injury. EGF did not affect the proliferation of E. coli in vitro. The findings suggest that EGF protects the gastrointestinal tract against colonization by enteropathogenic E. coli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.