ArticleBiophysical journal1998
Analysis of synaptic transmission in the neuromuscular junction using a continuum finite element model.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- GluD1 is localized at cholinergic synapses and is an acetylcholine receptor.Molecular psychiatry · 2026Article
- Fast analysis and engineering of protein function by microbe-independent deep assembly and screening.Molecular systems biology · 2026Article
- Acetylcholine waves and dopamine release in the striatum.Nature communications · 2023Article
- Chemically Fueled Self-Assembly in Biology and Chemistry.Angewandte Chemie (International ed. in English) · 2021Review
- Rapsyn facilitates recovery from desensitization in fetal and adult acetylcholine receptors expressed in a muscle cell line.The Journal of physiology · 2019Article
- Hybrid finite element and Brownian dynamics method for charged particles.The Journal of chemical physics · 2016Article
- Numerical calculation of protein-ligand binding rates through solution of the Smoluchowski equation using smoothed particle hydrodynamics.BMC biophysics · 2015Article
- Synaptic bouton properties are tuned to best fit the prevailing firing pattern.Frontiers in computational neuroscience · 2014Article
- Hybrid finite element and Brownian dynamics method for diffusion-controlled reactions.The Journal of chemical physics · 2012Article
- Multi-Scale Continuum Modeling of Biological Processes: From Molecular Electro-Diffusion to Sub-Cellular Signaling Transduction.Computational science & discovery · 2012Article
- Hydrodynamic flow in a synaptic cleft during exocytosis.European biophysics journal : EBJ · 2012Article
- Synergistic inhibition of butyrylcholinesterase by galantamine and citalopram.Biochimica et biophysica acta · 2011Article
- Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization.Bioorganic & medicinal chemistry · 2011Article
- A new 3D mass diffusion-reaction model in the neuromuscular junction.Journal of computational neuroscience · 2011Article
- A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction.BMC biophysics · 2011Article
- Finite element analysis of drug electrostatic diffusion: inhibition rate studies in N1 neuraminidase.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2009Article
- Finite element analysis of the time-dependent Smoluchowski equation for acetylcholinesterase reaction rate calculations.Biophysical journal · 2007Article
- Array feature size influences nucleic acid surface capture in DNA microarrays.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Continuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models.Biophysical chemistry · 2007Article
- Continuum diffusion reaction rate calculations of wild-type and mutant mouse acetylcholinesterase: adaptive finite element analysis.Biophysical journal · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a steadily growing body of experimental data describing the diffusion of acetylcholine in the neuromuscular junction and the subsequent miniature endplate currents produced at the postsynaptic membrane. To gain further insights into the structural features governing synaptic transmission, we have performed calculations using a simplified finite element model of the neuromuscular junction. The diffusing acetylcholine molecules are modeled as a continuum, whose spatial and temporal distribution is governed by the force-free diffusion equation. The finite element method was adopted because of its flexibility in modeling irregular geometries and complex boundary conditions. The resulting simulations are shown to be in accord with experiment and other simulations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.