ReviewMolecular and cellular biochemistry1998
In situ measurements of creatine kinase flux by NMR. The lessons from bioengineered mice.
Review in Molecular and cellular biochemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Quantification of creatine kinase reaction rate in mouse hindlimb using phosphorus-31 magnetic resonance spectroscopic fingerprinting.NMR in biomedicine · 2021Article
- Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake.The Journal of physiology · 2013Article
- Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency.The Journal of physiology · 2011Article
- Studying Enzymes by In Vivo C Magnetic Resonance Spectroscopy.Progress in nuclear magnetic resonance spectroscopy · 2009Article
- Presence of (phospho)creatine in developing and adult skeletal muscle of mice without mitochondrial and cytosolic muscle creatine kinase isoforms.The Journal of physiology · 2003Article
- In vivo (31)P-NMR diffusion spectroscopy of ATP and phosphocreatine in rat skeletal muscle.Biophysical journal · 2000Article
- Reduced activity of enzymes coupling ATP-generating with ATP-consuming processes in the failing myocardium.Molecular and cellular biochemistry · 1999Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
P-31 nuclear magnetic resonance (NMR) is uniquely suited to measure the kinetics of the phosphoryl-exchange reaction catalyzed by creatine kinase in intact mammalian tissue, especially striated muscle. Recently developed transgenic mouse models of the creatine kinase iso-enzyme system open novel opportunities to assess the functional importance of the individual iso-enzymes and their relative contribution to the total in situ flux through the CK reaction. This chapter reviews the most recent findings from NMR flux measurements on such genetic models of CK function. Findings in intact mouse skeletal and cardiac muscle in vivo are compared to data from purified mitochondrial and cytosolic creatine kinase in vitro. The relevance of findings in transgenic animals for the function of CK in wild-type tissue is described and the perspectives of transgenic techniques in future quantitative studies on the creatine kinase iso-enzyme system are indicated.
Indexed as
Identifiers
9746322W1514487934What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.