ReviewMolecular and cellular biochemistry1998
Molecular characterization of the creatine kinases and some historical perspectives.
Review in Molecular and cellular biochemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Diagnostic role of postmortem CK-MB in cardiac death: a systematic review and meta-analysis.Forensic science, medicine, and pathology · 2020Pooled it
- Gene delivery of AGAT and GAMT boosts creatine levels in creatine transporter deficiency patient fibroblasts.PloS one · 2025Article
- Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro.Archives of toxicology · 2021Article
- Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system.Bioscience reports · 2011Article
- Estrogen-related receptor α regulates skeletal myocyte differentiation via modulation of the ERK MAP kinase pathway.American journal of physiology. Cell physiology · 2011Article
- Exercise protects against MPTP-induced neurotoxicity in mice.Brain research · 2010Article
- The transcriptional cascade associated with creatine kinase down-regulation and mitochondrial biogenesis in mice sarcoma.Cellular & molecular biology letters · 2009Article
- Cytoplasmic and mitochondrial creatine kinases from the skeletal muscle of sperm whale (Physeter macrocephalus). Molecular cloning and enzyme characterization.The protein journal · 2008Article
- Evolution of the cytoplasmic and mitochondrial phosphagen kinases unique to annelid groups.Journal of molecular evolution · 2007Article
- Evolution and divergence of the genes for cytoplasmic, mitochondrial, and flagellar creatine kinases.Journal of molecular evolution · 2004Article
- The carp muscle-specific sub-isoenzymes of creatine kinase form distinct dimers at different temperatures.The Biochemical journal · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has paralleled the molecular revolution of understanding gene structure, function, and regulation. In this review, we present a summary of advances in molecular analysis of the CK gene family with a few vignettes of historical interest. We describe how the muscle CK gene provided an essential model system to examine myogenic regulatory mechanisms, leading to the discovery of the binding site for the MyoD family of basic helix-loop-helix transcription factors essential in skeletal myogenesis and the characterization of the MEF2 family of factors with an A/T rich consensus binding site essential in skeletal myogenesis and cardiogenesis. Cloning and characterization of the four mRNAs and nuclear genes encoding the cytosolic CKs, muscle and brain CKs, and the mitochondrial (Mt) CKs, sarcomeric MtCK and ubiquitous MtCK, has allowed intriguing study of tissue-specific and cell-specific expression of the different CKs and analysis of structural, functional, regulatory, and evolutionary relationships among both the four CK proteins and genes. Current and future studies focus on understanding both cellular energetics facilitated by the CK enzymes, especially energy channelling from the site of production, the mitochondrial matrix and inner membrane, to various cytosolic foci of utilization, and regulation of MtCK gene expression at the cell and tissue-specific level as models of regulation of energy producing genes.
Indexed as
Identifiers
9746319W1496743944What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.