ArticleThe Journal of cell biology1998
Blocking cytochrome c activity within intact neurons inhibits apoptosis.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 161 citations in OpenAlex.
- Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis.Immunological reviews · 2022Review
- Genetically encoded intrabodies as high-precision tools to visualize and manipulate neuronal function.Seminars in cell & developmental biology · 2022Article
- Supramolecular organizing centers at the interface of inflammation and neurodegeneration.Frontiers in immunology · 2022Review
- Membrane Depolarization Inhibits BIMMolecular neurobiology · 2021Article
- Anti‑inflammatory mechanism of berberine on lipopolysaccharide‑induced IEC‑18 models based on comparative transcriptomics.Molecular medicine reports · 2020Article
- The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress.The Journal of biological chemistry · 2020Article
- Apoptotic cell death regulation in neurons.The FEBS journal · 2019Review
- Anastasis: recovery from the brink of cell death.Royal Society open science · 2018Review
- A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.The Journal of cell biology · 2017Article
- The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation.The Journal of biological chemistry · 2016Article
- HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation.Frontiers in cellular neuroscience · 2015Article
- Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths.Molecular and cellular neurosciences · 2014Article
- Programmed cell death during neuronal development: the sympathetic neuron model.Cell death and differentiation · 2014Review
- Apoptotic cell death in neuroblastoma.Cells · 2013Article
- Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death.BMC genomics · 2011Article
- Activation of apoptosis by cytoplasmic microinjection of cytochrome c.Journal of visualized experiments : JoVE · 2011Article
- Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury.ASN neuro · 2009Article
- Genetic control of programmed cell death during animal development.Annual review of genetics · 2009Review
- Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.Nature cell biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome c has been shown to play a role in cell-free models of apoptosis. During NGF withdrawal-induced apoptosis of intact rat superior cervical ganglion (SCG) neurons, we observe the redistribution of cytochrome c from the mitochondria to the cytoplasm. This redistribution is not inhibited by the caspase inhibitor Z-Val-Ala-Asp-fluoromethylketone (ZVADfmk) but is blocked by either of the neuronal survival agents 8-(4-chlorophenylthio)adenosine 3':5'-cyclic monophosphate (CPT-cAMP) or cycloheximide. Moreover, microinjection of SCG neurons with antibody to cytochrome c blocks NGF withdrawal-induced apoptosis. However, microinjection of SCG neurons with cytochrome c does not alter the rate of apoptosis in either the presence or absence of NGF. These data suggest that cytochrome c is an intrinsic but not limiting component of the neuronal apoptotic pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.