Evidence map›Paper›PMID 9744491›Full record

ArticleBritish journal of cancer1998

Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.

G M Taylor, S Dearden, N Payne, M Ayres, D A Gokhale, J M Birch, V Blair, R F Stevens, A M Will, O B Eden

Open access · bronzeAbstract read
In one paragraph

Article in British journal of cancer, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Perspectives on the causes of childhood leukemia.Chemico-biological interactions · 2012
    Review
  10. Article
  11. Article
  12. Article
  13. Genetic susceptibility to childhood leukaemia.Radiation protection dosimetry · 2008
    Review
  14. Review
  15. Review
  16. Article
  17. Childhood leukaemia.BMJ (Clinical research ed.) · 2002
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

G M TaylorImmunogenetics Laboratory, St Mary's Hospital, Manchester, UK.
S Dearden
N Payne
M Ayres
D A Gokhale
J M Birch
V Blair
R F Stevens
A M Will
O B Eden
St Mary's Hospital · GBRoyal Manchester Children's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.

Indexed as

AllelesAntigen PresentationChildChild, PreschoolCommunicable DiseasesDisease SusceptibilityDNAFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHLA-DQ alpha-ChainsHLA-DQ AntigensHLA-DQ beta-ChainsHumansInfantDNAHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DQ AntigensHLA-DQB1 antigenHLA-DQ beta-Chains

Identifiers

PMID9744491
PMCPMC2063058
OpenAlexW1970866492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.