ArticleThe Journal of experimental medicine1998
Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 134 citations in OpenAlex.
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- Regulation of Tetraspanin CD63 in Chronic Myeloid Leukemia (CML): Single-Cell Analysis of Asymmetric Hematopoietic Stem Cell Division Genes.Bioengineering (Basel, Switzerland) · 2025Article
- SON is an essential mCell stem cell · 2023Article
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- Par-3 family proteins in cell polarity & adhesion.The FEBS journal · 2022Review
- Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis.Blood advances · 2021Article
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- Clones assemble! The clonal complexity of blood during ontogeny and disease.Experimental hematology · 2020Review
- The development of T cells from stem cells in mice and humans.Future science OA · 2017Review
- Integrated time-lapse and single-cell transcription studies highlight the variable and dynamic nature of human hematopoietic cell fate commitment.PLoS biology · 2017Article
- Multipotent hematopoietic progenitors divide asymmetrically to create progenitors of the lymphomyeloid and erythromyeloid lineages.Stem cell reports · 2014Article
- Determining cell division symmetry through the dissection of dividing cells using single-cell expression analysis.Nature protocols · 2014Article
- Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties.PloS one · 2012Article
- Signal transduction pathways regulating hematopoietic stem cell biology: introduction to a series of Spotlight Reviews.Leukemia · 2012Article
- Dynamics of mutant cells in hierarchical organized tissues.PLoS computational biology · 2011Article
- High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays.Nature methods · 2011Article
- Plasticity and maintenance of hematopoietic stem cells during development.Recent patents on biotechnology · 2011Review
- Insights into leukemia-initiating cell frequency and self-renewal from a novel canine model of leukemia.Experimental hematology · 2011Article
- Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells.Journal of cellular and molecular medicine · 2010Article
- High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability.Journal of cellular and molecular medicine · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Hematopoietic stem cells (HSCs) in adult marrow are believed to be derived from fetal liver precursors. To study cell kinetics involved in long-term hematopoiesis, we studied single-sorted candidate HSCs from fetal liver that were cultured in the presence of a mixture of stimulatory cytokines. After 8-10 d, the number of cells in primary cultures varied from <100 to >10,000 cells. Single cells in slow growing colonies were recloned upon reaching a 100-200 cell stage. Strikingly, the number of cells in subclones varied widely again. These results are indicative of asymmetric divisions in primitive hematopoietic cells in which proliferative potential and cell cycle properties are unevenly distributed among daughter cells. The continuous generation of functional heterogeneity among the clonal progeny of HSCs is in support of intrinsic control of stem cell fate and provides a model for the long-term maintenance of hematopoiesis in vitro and in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.