ArticleBritish journal of cancer1998
Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q.
Article in British journal of cancer, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
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- Implication of snoRNA U50 in human breast cancer.Journal of genetics and genomics = Yi chuan xue bao · 2009Article
- Tumor suppress genes screening analysis on 4q in sporadic colorectal carcinoma.World journal of gastroenterology · 2008Article
- Extra copies of chromosomes 16 and X in invasive breast carcinomas are related to aggressive phenotype and poor prognosis.Journal of clinical pathology · 2007Article
- Overexpression of decoy receptor 3 in hepatocellular carcinoma and its association with resistance to Fas ligand-mediated apoptosis.World journal of gastroenterology · 2005Article
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- CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation.British journal of cancer · 2001Article
- The mammary myoepithelial cell--Cinderella or ugly sister?Breast cancer research : BCR · 2001Review
- Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Mapping of genetic deletions on the long arm of chromosome 4 in human esophageal adenocarcinomas.The American journal of pathology · 1999Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative genomic hybridization was applied to map DNA gains and losses in 39 invasive ductal breast carcinomas. Frequent abnormalities included gains on chromosomal regions 1q, 8q, 11q12-13, 16p, 19, 20q and X as well as frequent losses on 1p, 5q, 6q, 9p, 11q, 13q and 16q. Furthermore, frequent losses on 4q (20 cases) and 21q (14 cases) were found for the first time in this tumour type. High copy number amplifications were observed at 8q12-24, 11q11-13 and 20q13-ter. Highly differentiated tumours were associated with gains on 1q and 11q12-13 along with losses on 1p21-22, 4q, 13q, 11q21-ter. Undifferentiated breast carcinomas were characterized by additional DNA imbalances, i.e. deletions of 5q13-23, all of chromosome 9, the centromeric part of chromosome 13 including band 13q14 and the overrepresentation of chromosome X. We speculate that these changes are associated with tumour progression of invasive ductal breast cancer.
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