ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life1998
A fission-fusion origin for life.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Hunting the Cell CycleLife (Basel, Switzerland) · 2024Article
- The transition from animal to human culture-simulating the social protocell hypothesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Article
- The Origin(s) of Cell(s): Pre-Darwinian Evolution from FUCAs to LUCA : To Carl Woese (1928-2012), for his Conceptual Breakthrough of Cellular Evolution.Journal of molecular evolution · 2021Article
- Article
- Can polarity-inverted membranes self-assemble on Titan?Science advances · 2020Article
- The Construction of Biological 'Inter-Identity' as the Outcome of a Complex Process of Protocell Development in Prebiotic Evolution.Frontiers in physiology · 2020Article
- Fission of Lipid-Vesicles by Membrane Phase Transitions in Thermal Convection.Scientific reports · 2019Article
- Successive Paradigm Shifts in the Bacterial Cell Cycle and Related Subjects.Life (Basel, Switzerland) · 2019Article
- Systems protobiology: origin of life in lipid catalytic networks.Journal of the Royal Society, Interface · 2018Review
- A recursive vesicle-based model protocell with a primitive model cell cycle.Nature communications · 2015Article
- Why do bacteria divide?Frontiers in microbiology · 2015Article
- Molecular complementarity between simple, universal molecules and ions limited phenotype space in the precursors of cells.Biology direct · 2014Article
- New approaches to the problem of generating coherent, reproducible phenotypes.Theory in biosciences = Theorie in den Biowissenschaften · 2014Article
- How did metabolism and genetic replication get married?Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2012Article
- Polyvalent choline phosphate as a universal biomembrane adhesive.Nature materials · 2012Article
- Theory of the origin, evolution, and nature of life.Life (Basel, Switzerland) · 2011Article
- Computing with bacterial constituents, cells and populations: from bioputing to bactoputing.Theory in biosciences = Theorie in den Biowissenschaften · 2011Review
- Lack of evolvability in self-sustaining autocatalytic networks constraints metabolism-first scenarios for the origin of life.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Question 7: the first units of life were not simple cells.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To develop a comprehensive 'cells-first' approach to the origin of life, we propose that protocells form spontaneously and that the fission and fusion of these protocells drives the dynamics of their evolution. The fitness criterion for this evolution is taken to be the the stability (conservation) of domains in the protocellular membrane as determined by non-covalent molecular associations between the amphiphiles of the membrane and a subset of the macromolecules in the protocell. In the presence of a source of free energy the macromolecular content of the protocell (co-)evolves as the result of (domain-dependent) membrane-catalysed polymerisation of the prebiotic constituents delivered to the protocell by fusion. The metabolism of the cell therefore (co-)evolves on a rugged fitness landscape. We indicate how domain evolution with the same fitness criterion can potentially give rise to coding. Membrane domains may therefore provide the link between protocells and the RNA/DNA-world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.