ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Cellular and synaptic modulation underlying substance P-mediated plasticity of the lamprey locomotor network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Respiratory frequency plasticity during development.Respiratory physiology & neurobiology · 2019Review
- Gβγ SNARE Interactions and Their Behavioral Effects.Neurochemical research · 2019Review
- Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic.Frontiers in neuroscience · 2019Review
- Short-Term Synaptic Plasticity at Interneuronal Synapses Could Sculpt Rhythmic Motor Patterns.Frontiers in neural circuits · 2016Article
- Tectal microcircuit generating visual selection commands on gaze-controlling neurons.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Substance P Depolarizes Lamprey Spinal Cord Neurons by Inhibiting Background Potassium Channels.PloS one · 2015Article
- Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses.Neural plasticity · 2015Article
- Neuropeptide modulation of microcircuits.Current opinion in neurobiology · 2012Review
- Manipulations of spinal cord excitability evoke developmentally-dependent compensatory changes in the lamprey spinal cord.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Some principles of organization of spinal neurons underlying locomotion in zebrafish and their implications.Annals of the New York Academy of Sciences · 2010Article
- The contribution of synaptic inputs to sustained depolarizations in reticulospinal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Metaplastic facilitation and ultrastructural changes in synaptic properties are associated with long-term modulation of the lamprey locomotor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Gating and braking of short- and long-term modulatory effects by interactions between colocalized neuromodulators.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Ion channels of importance for the locomotor pattern generation in the lamprey brainstem-spinal cord.The Journal of physiology · 2001Review
- Tachykinin-related peptide and GABA-mediated presynaptic inhibition of crayfish photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Distinct functions for cotransmitters mediating motor pattern selection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Activity-dependent metaplasticity of inhibitory and excitatory synaptic transmission in the lamprey spinal cord locomotor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Modeling of substance P and 5-HT induced synaptic plasticity in the lamprey spinal CPG: consequences for network pattern generation.Journal of computational neuroscienceArticle
- Spinal-Cord plasticity: independent and interactive effects of neuromodulator and activity-dependent plasticity.Molecular neurobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The tachykinin substance P modulates the lamprey locomotor network by increasing the frequency of NMDA-evoked ventral root bursts and by making the burst activity more regular. These effects can last in excess of 24 hr. In this paper, the effects of substance P on the synaptic and cellular properties of motor neurons and identified network interneurons have been examined. Substance P potentiated the amplitude of monosynaptic glutamatergic inputs from excitatory interneurons and reticulospinal axons. The amplitude and frequency of miniature EPSPs was increased, suggesting that the synaptic modulation was mediated presynaptically and postsynaptically. The postsynaptic modulation was caused by a specific effect of substance P on the NMDA component of the synaptic input, whereas the presynaptic component was calcium-independent. Substance P did not affect monosynaptic glycinergic inputs from lateral interneurons, crossed inhibitory interneurons, or ipsilateral segmental interneurons or postsynaptic GABAA or GABAB responses, suggesting that it has little effect on inhibitory synaptic transmission. At the cellular level, substance P increased synaptic inputs, resulting in membrane potential oscillations in motor neurons, crossed caudal interneurons, lateral interneurons, and excitatory interneurons. The spiking in response to depolarizing current pulses was increased in motor neurons, lateral interneurons, and excitatory interneurons, but usually was reduced in crossed inhibitory interneurons. Substance P reduced the calcium-dependent afterhyperpolarization after an action potential in motor neurons and lateral interneurons, but did not affect this conductance in excitatory or crossed inhibitory interneurons. The relevance of these cellular and synaptic changes to the modulation of the locomotor network is discussed.
Indexed as
Identifiers
9742176PMC6793019W1960858470What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.