ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Genetic analysis on the role of integrin during axon guidance in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- The control of Plexin A-mediated axon guidance by the Src family kinase Src64B in Drosophila.Genes & genomics · 2026Article
- Integrin ligands block mechanical signal transduction in baroreceptors.Life science alliance · 2023Article
- Over-expression of Hsp83 in grossly depletedJournal of biosciences · 2019Article
- Cell adhesion and invasion mechanisms that guide developing axons.Current opinion in neurobiology · 2016Review
- On the Teneurin track: a new synaptic organization molecule emerges.Frontiers in cellular neuroscience · 2015Review
- Src inhibits midline axon crossing independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) receptor tyrosine phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The extracellular matrix proteoglycan perlecan facilitates transmembrane semaphorin-mediated repulsive guidance.Genes & development · 2012Article
- 14-3-3ε couples protein kinase A to semaphorin signaling and silences plexin RasGAP-mediated axonal repulsion.Neuron · 2012Article
- Extracellular matrix in development: insights from mechanisms conserved between invertebrates and vertebrates.Cold Spring Harbor perspectives in biology · 2011Review
- Extracellular matrix and its receptors in Drosophila neural development.Developmental neurobiology · 2011Review
- Article
- Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth.Neural development · 2008Article
- Genome-wide analyses of human perisylvian cerebral cortical patterning.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Genetic modifiers of Drosophila palmitoyl-protein thioesterase 1-induced degeneration.Genetics · 2007Article
- Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Molecular and comparative genetics of mental retardation.Genetics · 2004Article
- Integrins regulate responsiveness to slit repellent signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- small bristles is required for the morphogenesis of multiple tissues during Drosophila development.Genetics · 2001Article
- short stop is allelic to kakapo, and encodes rod-like cytoskeletal-associated proteins required for axon extension.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Dynamic visualization of nervous system in live Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Heterodimeric cell surface receptor integrin is widely expressed in the nervous system, but its specific role during axon development has not been directly tested in vivo. We show that the Drosophila nervous system expresses low levels of positron-specific (PS) integrin subunits alphaPS1, alphaPS2, and betaPS during embryonic axogenesis. Furthermore, certain subsets of neurons express higher levels of integrin mRNAs than do the rest. Null mutations in either the alphaPS1 or alphaPS2 subunit gene cause widespread axon pathfinding errors that can be rescued by supplying the wild-type integrin subunit to the mutant nervous system. In contrast, misexpressing either the alphaPS1 or alphaPS2 integrin subunit in all neurons leads to no obvious axon pathfinding errors. We propose that integrin does not itself serve as either a "clutch" constituting molecule or a specific growth cone "receptor," as proposed previously, but rather as part of a molecular network that cooperatively guarantees accurate axon guidance.
Indexed as
Identifiers
9742153PMC6793012W2097861390What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.